sdk sidekick [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sdkprovided by FlyBase
Official Full Name: sidekickprovided by FlyBase
Primary source: FLYBASE:FBgn0021764
Locus tag: Dmel_CG5227
See related: AllianceGenome:FB:FBgn0021764
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD22322; BcDNA:RE63453; CG5227; CT16627; Dmel\CG5227; EG:BACR19J1.1; Sdk; Sidekick
Summary: Enables cell adhesion receptor activity. Involved in several processes, including compound eye cone cell differentiation; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of photoreceptor cell differentiation. Located in apical part of cell. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval optic lobe; optic lobe intrinsic columnar neurons; and outer photoreceptor cell. Used to study obesity. Orthologous to human SDK1 (sidekick cell adhesion molecule 1) and SDK2 (sidekick cell adhesion molecule 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1C2-1C3; 1-0 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (686834..749496)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (580867..643529)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sidekick dynamically rebalances contractile and protrusive forces to control tissue morphogenesis.
Title: Sidekick dynamically rebalances contractile and protrusive forces to control tissue morphogenesis.
Sdk is required for myosin II accumulation at new junctions. Sdk delays E-Cadherin accumulation at new junctions to assist their growth.
Title: The Tricellular Junction Protein Sidekick Regulates Vertex Dynamics to Promote Bicellular Junction Extension.
Sidekick is necessary for normal cell and junctional rearrangements. Sidekick links actin filaments to vertices through Canoe and Polychaetoid.
Title: Sidekick Is a Key Component of Tricellular Adherens Junctions that Acts to Resolve Cell Rearrangements.
Sidekick is required in photoreceptors, but not in their target lamina neurons, to promote the alignment of lamina neurons into columns and subsequent sorting of photoreceptor axons into synaptic modules based on their precise spatial orientation.
Title: Drosophila Sidekick is required in developing photoreceptors to enable visual motion detection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 694087-694136 mobile_element_type = transposon:INE-1{}5267
Loc: 694168-694458 mobile_element_type = transposon:INE-1{}5271
Loc: 705209-705566 mobile_element_type = transposon:INE-1{}5274
Loc: 710616-711119 mobile_element_type = transposon:INE-1{}5276
Loc: 718818-718919 mobile_element_type = transposon:INE-1{}5277
Loc: 721699-722107 mobile_element_type = transposon:INE-1{}5290

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pigment cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in perivitelline space	HDA more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: sidekick

Names: CG5227-PA; CG5227-PB; CG5227-PC; CG5227-PD; CG5227-PE; CG5227-PF; CG5227-PG; CG5227-PH; CG5227-PI; sdk-PA; sdk-PB; sdk-PC; sdk-PD; sdk-PE; sdk-PF; sdk-PG; sdk-PH; sdk-PI

NP_001162630.1

sequencing error

NP_001162631.1

sequencing error

NP_001284756.1

sequencing error

NP_001284757.1

sequencing error

NP_001284758.1

sequencing error

NP_477289.5

sequencing error

NP_477290.6

sequencing error

NP_599141.5

sequencing error

NP_599142.5

sequencing error

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

686834..749496

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169159.2 → NP_001162630.1 sidekick, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162630.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3T7, A9UNG5, O97394, Q0KHX5, Q86BQ7, Q9U1M1, Q9UB11, Q9W5D9

UniProtKB/TrEMBL

C8VV85, E1JJC3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1787 → 1879

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1276 → 1361

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain
NM_057942.5 → NP_477290.6 sidekick, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477290.6

Status: REVIEWED

UniProtKB/TrEMBL

C8VV85

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1787 → 1879

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1276 → 1361

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain
NM_134315.4 → NP_599142.5 sidekick, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599142.5

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3T7, A9UNG5, O97394, Q0KHX5, Q86BQ7, Q9U1M1, Q9UB11, Q9W5D9

UniProtKB/TrEMBL

C8VV85, E1JJC3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1787 → 1879

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1276 → 1361

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain
NM_001297827.1 → NP_001284756.1 sidekick, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284756.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV85, X2JHT7

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:506 → 587

IG_like; Immunoglobulin like

cd00063
Location:1828 → 1920

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:592 → 682

I-set; Immunoglobulin I-set domain

pfam00041
Location:1317 → 1402

fn3; Fibronectin type III domain

cl11960
Location:506 → 587

Ig; Immunoglobulin domain
NM_134314.4 → NP_599141.5 sidekick, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_599141.5

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3T7, A9UNG5, O97394, Q0KHX5, Q86BQ7, Q9U1M1, Q9UB11, Q9W5D9

UniProtKB/TrEMBL

C8VV85, E1JJC3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1787 → 1879

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1276 → 1361

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain
NM_001297828.1 → NP_001284757.1 sidekick, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284757.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV85, X2JDB3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1783 → 1875

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1272 → 1357

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain
NM_001297829.1 → NP_001284758.1 sidekick, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284758.1

Status: REVIEWED

UniProtKB/TrEMBL

C8VV85, X2JDR3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:375 → 450

IG_like; Immunoglobulin like

cd00063
Location:1731 → 1823

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:495 → 585

I-set; Immunoglobulin I-set domain

pfam00041
Location:1220 → 1305

fn3; Fibronectin type III domain

cl11960
Location:71 → 157

Ig; Immunoglobulin domain
NM_057941.5 → NP_477289.5 sidekick, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477289.5

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3T7, A9UNG5, O97394, Q0KHX5, Q86BQ7, Q9U1M1, Q9UB11, Q9W5D9

UniProtKB/TrEMBL

C8VV85, E1JJC3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1787 → 1879

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1276 → 1361

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain
NM_001169160.2 → NP_001162631.1 sidekick, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V3T7, A9UNG5, O97394, Q0KHX5, Q86BQ7, Q9U1M1, Q9UB11, Q9W5D9

UniProtKB/TrEMBL

C8VV85, E1JJC3

Conserved Domains (6) summary

cd00096
Location:378 → 447

Ig; Immunoglobulin domain

smart00410
Location:461 → 542

IG_like; Immunoglobulin like

cd00063
Location:1787 → 1879

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:547 → 637

I-set; Immunoglobulin I-set domain

pfam00041
Location:1276 → 1361

fn3; Fibronectin type III domain

cl11960
Location:461 → 542

Ig; Immunoglobulin domain