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    Mct1 Monocarboxylate transporter 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mct1provided by FlyBase
    Official Full Name
    Monocarboxylate transporter 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023549
    Locus tag
    Dmel_CG3456
    See related
    AllianceGenome:FB:FBgn0023549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3456; Dmel\CG3456; EG:103B4.3; MCT1
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to several human genes including SLC16A14 (solute carrier family 16 member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mct1 in Genome Data Viewer
    Location:
    2E1-2E2; 1-0.8 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2189188..2205373)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2083221..2099406)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43637 Neighboring gene Fatty acyl-CoA reductase in oenocytes Neighboring gene SET and MYND domain containing, arthropod-specific, member 8 Neighboring gene Vinculin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lessons from modENCODE. Brown JB, et al. Annu Rev Genomics Hum Genet, 2015. PMID 26133010
    2. Glial Synaptobrevin mediates peripheral nerve insulation, neural metabolic supply, and is required for motor function. Böhme MA, et al. Glia, 2021 Aug. PMID 33811396
    3. Alternative mechanisms for talin to mediate integrin function. Klapholz B, et al. Curr Biol, 2015 Mar 30. PMID 25754646, Free PMC Article
    4. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article
    5. The NMDA receptor regulates competition of epithelial cells in the Drosophila wing. Banreti AR, et al. Nat Commun, 2020 May 6. PMID 32376880, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 1
    Names
    CG3456-PA
    CG3456-PB
    Mct1-PA
    Mct1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2189188..2205373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297881.1 → NP_001284810.1  monocarboxylate transporter 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46039, Q9UB81, Q9W509
      Conserved Domains (1) summary
      cd06174
      Location:426 → 604
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_057986.4 → NP_477334.2  monocarboxylate transporter 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477334.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46039, Q9UB81, Q9W509
      Related
      FBpp0070377
      Conserved Domains (1) summary
      cd06174
      Location:426 → 604
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UB81 Q9UB81
    Q9W509 Q9W509

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