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    Rnp4F RNA-binding protein 4F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnp4Fprovided by FlyBase
    Official Full Name
    RNA-binding protein 4Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014024
    Locus tag
    Dmel_CG3312
    See related
    AllianceGenome:FB:FBgn0014024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4f-rnp; 4F-rnp; CG3312; Dmel\CG3312; rnp-4f; Rnp-4F; RNP-4F; Rnp4f
    Summary
    Predicted to enable mRNA binding activity. Involved in central nervous system development. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; gut section; and neuron projection bundle of larval ventral nerve cord. Orthologous to human SART3 (spliceosome associated factor 3, U4/U6 recycling protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rnp4F in Genome Data Viewer
    Location:
    4F5-4F5; 1-11 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5318928..5322696, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5212961..5216729, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene deadhead Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Something about silencing 10 Neighboring gene Minichromosome maintenance 3 Neighboring gene uncharacterized protein Neighboring gene XRCC1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA editing in Drosophila 4f-rnp gene nuclear transcripts by multiple A-to-G conversions. Petschek JP, et al. J Mol Biol, 1996 Jun 28. PMID 8683590
    2. Spatial and temporal expression of 4f-rnp gene in Drosophila melanogaster. Hess KA, et al. Differentiation, 1996 Dec. PMID 8983176
    3. RNA editing and alternative splicing generate mRNA transcript diversity from the Drosophila 4f-rnp locus. Petschek JP, et al. Gene, 1997 Dec 19. PMID 9434193
    4. The evolution of single-copy Drosophila nuclear 4f-rnp genes: spliceosomal intron losses create polymorphic alleles. Feiber AL, et al. J Mol Evol, 2002 Oct. PMID 12355261
    5. 5'-UTR mediated translational control of splicing assembly factor RNP-4F expression during development of the Drosophila central nervous system. Chen J, et al. Gene, 2013 Oct 10. PMID 23892091

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNP-4F translational regulation is highly sensitive in the developing fly central nervous system.
      Title: 5'-UTR mediated translational control of splicing assembly factor RNP-4F expression during development of the Drosophila central nervous system.
    2. Long rnp-4f mRNA knockdown via RNAi reveals a variety of CNS abnormalities, which leads us to postulate that this isoform acts upstream of other genes which have been shown to be important for normal CNS development.
      Title: Alternative splicing of an rnp-4f mRNA isoform retaining an evolutionarily-conserved 5'-UTR intronic element is developmentally regulated and shown via RNAi to be essential for normal central nervous system development in Drosophila melanogaster.
    3. RNA editing and regulation of 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts.
      Title: RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts.
    4. model is proposed for the role of this element both in 5'-UTR alternative splicing decisions and in RNP-4F translational modulation
      Title: Alternative pre-mRNA splicing in Drosophila spliceosomal assembly factor RNP-4F during development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ASAP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 4F
    Names
    CG3312-PA
    CG3312-PB
    CG3312-PD
    CG3312-PF
    Rnp4F-PA
    Rnp4F-PB
    Rnp4F-PD
    Rnp4F-PF
    splicing assembly factor rnp-4f

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5318928..5322696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103414.3 → NP_001096884.1  RNA-binding protein 4F, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Z4, O18351, O18352, Q2VC69, Q2VC70, Q2VC71, Q2VC72, Q2VC73, Q2XP46, Q9W4D2
      UniProtKB/TrEMBL
      A8JUY0, A8JUY2
      Conserved Domains (4) summary
      COG0724
      Location:681 → 811
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam03985
      Location:816 → 922
      Paf1; Paf1
      pfam05391
      Location:922 → 940
      Lsm_interact; Lsm interaction motif
      cl17169
      Location:722 → 802
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_206630.3 → NP_996353.1  RNA-binding protein 4F, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Z4, O18351, O18352, Q2VC69, Q2VC70, Q2VC71, Q2VC72, Q2VC73, Q2XP46, Q9W4D2
      UniProtKB/TrEMBL
      A8JUY0, A8JUY2
      Conserved Domains (4) summary
      COG0724
      Location:681 → 811
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam03985
      Location:816 → 922
      Paf1; Paf1
      pfam05391
      Location:922 → 940
      Lsm_interact; Lsm interaction motif
      cl17169
      Location:722 → 802
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_078492.4 → NP_511047.2  RNA-binding protein 4F, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511047.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Z4, O18351, O18352, Q2VC69, Q2VC70, Q2VC71, Q2VC72, Q2VC73, Q2XP46, Q9W4D2
      UniProtKB/TrEMBL
      A8JUY0, A8JUY2
      Related
      FBpp0070720
      Conserved Domains (4) summary
      COG0724
      Location:681 → 811
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam03985
      Location:816 → 922
      Paf1; Paf1
      pfam05391
      Location:922 → 940
      Lsm_interact; Lsm interaction motif
      cl17169
      Location:722 → 802
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001103413.3 → NP_001096883.3  RNA-binding protein 4F, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096883.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Z4, O18351, O18352, Q2VC69, Q2VC70, Q2VC71, Q2VC72, Q2VC73, Q2XP46, Q9W4D2
      UniProtKB/TrEMBL
      A8JUY0, A8JUY2
      Conserved Domains (4) summary
      COG0724
      Location:681 → 811
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam03985
      Location:816 → 922
      Paf1; Paf1
      pfam05391
      Location:922 → 940
      Lsm_interact; Lsm interaction motif
      cl17169
      Location:722 → 802
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JUY0 A8JUY0
    Q9W4D2.1 Q9W4D2

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