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    pigs pickled eggs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pigsprovided by FlyBase
    Official Full Name
    pickled eggsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029881
    Locus tag
    Dmel_CG3973
    See related
    AllianceGenome:FB:FBgn0029881
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3973; Dmel\CG3973; pig
    Summary
    Predicted to enable actin filament binding activity. Involved in follicle cell of egg chamber stalk formation and negative regulation of Notch signaling pathway. Colocalizes with actin cytoskeleton and cytoplasmic microtubule. Is expressed in adepithelial cell of wing disc and spermatozoon. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 41. Orthologous to several human genes including GAS2L1 (growth arrest specific 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pigs in Genome Data Viewer
    Location:
    6C1-6C3; 1-18 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6600062..6653015)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6494095..6547048)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43832 Neighboring gene Protein interacting with APP tail-1 Neighboring gene Anaphase Promoting Complex subunit 7 Neighboring gene long non-coding RNA:CR44817 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cdc7 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Gas2 family protein Pigs is a microtubule +TIP that affects cytoskeleton organisation. Girdler GC, et al. J Cell Sci, 2016 Jan 1. PMID 26585311, Free PMC Article
    2. FB elements can promote exon shuffling: a promoter-less white allele can be reactivated by FB mediated transposition in Drosophila melanogaster. Moschetti R, et al. Mol Genet Genomics, 2004 May. PMID 15060822
    3. Structured inquiry-based learning: Drosophila GAL4 enhancer trap characterization in an undergraduate laboratory course. Dunne CR, et al. PLoS Biol, 2014 Dec. PMID 25549104, Free PMC Article
    4. Transcriptomic and functional genetic evidence for distinct ecophysiological responses across complex life cycle stages. Freda PJ, et al. J Exp Biol, 2022 Jun 1. PMID 35578907
    5. The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families. Röper K, et al. J Cell Sci, 2002 Nov 15. PMID 12376554

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber stalk formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickled eggs
    Names
    CG3973-PA
    CG3973-PB
    CG3973-PC
    pigs-PA
    pigs-PB
    pigs-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6600062..6653015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298020.1 → NP_001284949.1  pickled eggs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284949.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TD5, Q9W3Y4
      Conserved Domains (2) summary
      cd00014
      Location:22 → 159
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam02187
      Location:258 → 325
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    2. NM_132103.3 → NP_572331.2  pickled eggs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572331.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TD5, Q9W3Y4
      Related
      FBpp0070909
      Conserved Domains (2) summary
      cd00014
      Location:22 → 159
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam02187
      Location:258 → 325
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    3. NM_001258621.2 → NP_001245550.1  pickled eggs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TD5, Q9W3Y4
      Conserved Domains (2) summary
      cd00014
      Location:22 → 159
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam02187
      Location:258 → 325
      GAS2; Growth-Arrest-Specific Protein 2 Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3Y4.2 Q9W3Y4

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