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    CG3226 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3226provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029882
    Locus tag
    Dmel_CG3226
    See related
    AllianceGenome:FB:FBgn0029882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3226; Q9W3Y3
    Summary
    Predicted to enable S100 protein binding activity; tubulin binding activity; and ubiquitin protein ligase binding activity. Involved in heart development. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human CACYBP (calcyclin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3226 in Genome Data Viewer
    Location:
    6C3-6C3; 1-18 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6653113..6654248, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6547146..6548281, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene pickled eggs Neighboring gene long non-coding RNA:CR44817 Neighboring gene uncharacterized protein Neighboring gene Cdc7 kinase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. Garcia-Ranea JA, et al. FEBS Lett, 2002 Oct 9. PMID 12372593
    2. Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. Casad ME, et al. Mol Genet Genomics, 2012 Apr. PMID 22398840, Free PMC Article
    3. The cytolinker Pigs is a direct target and a negative regulator of Notch signalling. Pines MK, et al. Development, 2010 Mar. PMID 20150280, Free PMC Article
    4. The Hippo signaling pathway interactome. Kwon Y, et al. Science, 2013 Nov 8. PMID 24114784, Free PMC Article
    5. A microtubule interactome: complexes with roles in cell cycle and mitosis. Hughes JR, et al. PLoS Biol, 2008 Apr 22. PMID 18433294, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S100 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3226-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6653113..6654248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132104.4 → NP_572332.1  uncharacterized protein Dmel_CG3226 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3Y3
      Related
      FBpp0070953
      Conserved Domains (2) summary
      cd06468
      Location:68 → 159
      p23_CacyBP; p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter ...
      pfam09032
      Location:3 → 60
      Siah-Interact_N; Siah interacting protein, N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3Y3 Q9W3Y3

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