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    nonC no-on-and-no-off transient C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31625, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nonCprovided by FlyBase
    Official Full Name
    no-on-and-no-off transient Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263968
    Locus tag
    Dmel_CG32743
    See related
    AllianceGenome:FB:FBgn0263968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.24; anon-WO0170980.133; CG32743; CG4549; CG4555; clone 1.24; Dmel\CG32743; dSmg1; rst(1a)cyr; Smg; smg1; Smg1; SMG1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including neuromuscular synaptic transmission; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and synaptic vesicle transport. Predicted to be part of TOR complex. Predicted to be active in cytoplasm and nucleus. Is expressed in peripodial epithelium of eye disc. Orthologous to human SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nonC in Genome Data Viewer
    Location:
    6D3-6D4; 1-18 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6824496..6838122)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6718529..6732155)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene xiantuan Neighboring gene Ataxin 1 Neighboring gene muscarinic Acetylcholine Receptor, C-type Neighboring gene uncharacterized protein Neighboring gene TATA element modulatory factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Chen Z, et al. Genetics, 2005 Sep. PMID 15965240, Free PMC Article
    2. Positional cloning of a cyromazine resistance gene in Drosophila melanogaster. Chen Z, et al. Insect Mol Biol, 2006 Apr. PMID 16640728
    3. In search of proteins that are important for synaptic functions in Drosophila visual system. Kim E, et al. J Neurogenet, 2012 Jun. PMID 22283835
    4. Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila. Nelson JO, et al. Genetics, 2018 Aug. PMID 29903866, Free PMC Article
    5. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Song YH, et al. Curr Biol, 2004 Aug 10. PMID 15296752

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. maintains synapse architecture and synaptic vesicle cycling
      Title: The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.
    2. Results show that two nonsense alleles of the ortholog of Smg1 do not affect nonsense-mediated mRNA decay.
      Title: Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster.
    3. RNAi experiments confirm that cyromazine resistance can be achieved by knocking down CG32743.
      Title: Positional cloning of a cyromazine resistance gene in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuromuscular synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TOR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    no-on-and-no-off transient C
    Names
    CG32743-PA
    CG32743-PB
    FRAP-related
    Smg1
    no on or off transient C
    nonC-PA
    nonC-PB
    resistance 1a cyromazine
    NP_001284967.1
    NP_727132.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6824496..6838122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298038.1 → NP_001284967.1  no-on-and-no-off transient C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP14, Q70PP2, Q9W3V6
      UniProtKB/TrEMBL
      X2JDZ8
      Conserved Domains (4) summary
      cd05170
      Location:1894 → 2196
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:3189 → 3217
      FATC; FATC domain
      pfam08771
      Location:1738 → 1845
      Rapamycin_bind; Rapamycin binding domain
      pfam15785
      Location:571 → 1140
      SMG1; Serine/threonine-protein kinase smg-1

    2. NM_167095.3 → NP_727132.1  no-on-and-no-off transient C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727132.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NP14, Q70PP2, Q9W3V6
      UniProtKB/TrEMBL
      X2JDZ8
      Related
      FBpp0070933
      Conserved Domains (4) summary
      cd05170
      Location:1894 → 2196
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:3189 → 3217
      FATC; FATC domain
      pfam08771
      Location:1738 → 1845
      Rapamycin_bind; Rapamycin binding domain
      pfam15785
      Location:571 → 1140
      SMG1; Serine/threonine-protein kinase smg-1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70PP2.2 Q70PP2
    X2JDZ8 X2JDZ8

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