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    Gclc Glutamate-cysteine ligase catalytic subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53581, updated on 17-Dec-2024

    Summary

    Official Symbol
    Gclcprovided by FlyBase
    Official Full Name
    Glutamate-cysteine ligase catalytic subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040319
    Locus tag
    Dmel_CG2259
    See related
    AllianceGenome:FB:FBgn0040319
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2259; CG2259; Dmel\CG2259; DmGCLC; DmGCS; DmGCSh; GCL; gclc; gclC; GclC; GCLc; GCLC; Gcs; Gcsh; GCSh; mTOR
    Summary
    Enables glutamate-cysteine ligase activity. Involved in several processes, including glutathione biosynthetic process; imaginal disc-derived wing morphogenesis; and response to copper ion. Located in nucleus and perinuclear region of cytoplasm. Part of glutamate-cysteine ligase complex. Is expressed in embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Gclc in Genome Data Viewer
    Location:
    7D6-7D6; 1-22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8102181..8116147, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7996214..8010180, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin conjugating enzyme E2H Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cypher Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutamate-cysteine ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate-cysteine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutamate-cysteine ligase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables glutamate-cysteine ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutathione biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glutathione biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to copper ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to copper ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of glutamate-cysteine ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Glutamate-cysteine ligase catalytic subunit
    Names
    CG2259-PA
    CG2259-PB
    CG2259-PC
    CG2259-PD
    Gclc-PA
    Gclc-PB
    Gclc-PC
    Gclc-PD
    catalytic subunit of glutamate- cysteine ligase
    gamma-Glutamylcysteine synthetase
    gamma-Glutamylcysteine synthetase catalytic subunit
    gamma-glutamylcysteine ligase
    glutamate cysteine ligase
    glutamate-cysteine ligase
    NP_001285001.1
    NP_001285002.1
    NP_525005.2
    NP_996373.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8102181..8116147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298072.1NP_001285001.1  Glutamate-cysteine ligase catalytic subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285001.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGQ3, Q9W3K5
      UniProtKB/TrEMBL
      A4V448
      Conserved Domains (1) summary
      pfam03074
      Location:232675
      GCS; Glutamate-cysteine ligase
    2. NM_080266.3NP_525005.2  Glutamate-cysteine ligase catalytic subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525005.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGQ3, Q9W3K5
      UniProtKB/TrEMBL
      A4V448
      Related
      FBpp0071063
      Conserved Domains (1) summary
      pfam03074
      Location:232675
      GCS; Glutamate-cysteine ligase
    3. NM_001298073.1NP_001285002.1  Glutamate-cysteine ligase catalytic subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGQ3, Q9W3K5
      UniProtKB/TrEMBL
      A4V448
      Conserved Domains (1) summary
      pfam03074
      Location:232675
      GCS; Glutamate-cysteine ligase
    4. NM_206650.2NP_996373.1  Glutamate-cysteine ligase catalytic subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996373.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NGQ3, Q9W3K5
      UniProtKB/TrEMBL
      A4V448
      Conserved Domains (1) summary
      pfam03074
      Location:232675
      GCS; Glutamate-cysteine ligase