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    CG12116 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31782, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12116provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030041
    Locus tag
    Dmel_CG12116
    See related
    AllianceGenome:FB:FBgn0030041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    144701_at; Dmel\CG12116
    Summary
    Predicted to enable sepiapterin reductase (NADP+) activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12116 in Genome Data Viewer
    Location:
    7F1-7F1; 1-23 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8467443..8469012, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8361476..8363045, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Es2 Neighboring gene Sepiapterin reductase Neighboring gene uncharacterized protein Neighboring gene Chorion protein a at 7F Neighboring gene Chorion protein b at 7F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by Downregulating Litopenaeus vannamei Sepiapterin Reductase to Promote White Spot Syndrome Virus Replication. Wang W, et al. Front Microbiol, 2021. PMID 35003027, Free PMC Article
    2. Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster. Wilinski D, et al. Nat Commun, 2019 Sep 6. PMID 31492856, Free PMC Article
    3. Drosophila FIT is a protein-specific satiety hormone essential for feeding control. Sun J, et al. Nat Commun, 2017 Jan 19. PMID 28102207, Free PMC Article
    4. The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila. Duneau DF, et al. BMC Biol, 2017 Dec 21. PMID 29268741, Free PMC Article
    5. The ups and downs of daily life: profiling circadian gene expression in Drosophila. Etter PD, et al. Bioessays, 2002 Jun. PMID 12111731

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sepiapterin reductase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12116-PA
    NP_572481.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8467443..8469012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132253.2 → NP_572481.1  uncharacterized protein Dmel_CG12116 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572481.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3F1
      Related
      FBpp0071183
      Conserved Domains (2) summary
      cd05367
      Location:13 → 269
      SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs
      COG1028
      Location:6 → 212
      FabG; NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3F1 Q9W3F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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