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    Gr8a Gustatory receptor 8a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gr8aprovided by FlyBase
    Official Full Name
    Gustatory receptor 8aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030108
    Locus tag
    Dmel_CG15371
    See related
    AllianceGenome:FB:FBgn0030108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15371; Dmel\CG15371; GR8a; Gr8D1
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Involved in chemosensory behavior; response to L-canavanine; and response to insecticide. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in several structures, including adult labellum sensillum; adult neuromere; adult oenocyte; ejaculatory bulb; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gr8a in Genome Data Viewer
    Location:
    8D2-8D2; 1-27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9227137..9228827)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9121170..9122860)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene tan Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ionotropic receptor 8a Neighboring gene mir-4916 stem loop Neighboring gene multi sex combs

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Coupling of Mate Recognition Systems in the Genomic Era. Ritchie MG, et al. Cold Spring Harb Perspect Biol, 2024 Apr 1. PMID 38316558,
    2. Reduced X-linked rare polymorphism in males in comparison to females of Drosophila melanogaster. Takahashi KH, et al. J Hered, 2009 Jan-Feb. PMID 18836147
    3. A genome-wide, fine-scale map of natural pigmentation variation in Drosophila melanogaster. Bastide H, et al. PLoS Genet, 2013 Jun. PMID 23754958, Free PMC Article
    4. Ancient balancing selection at tan underlies female colour dimorphism in Drosophila erecta. Yassin A, et al. Nat Commun, 2016 Jan 18. PMID 26778363, Free PMC Article
    5. The evolution of gene regulation underlies a morphological difference between two Drosophila sister species. Jeong S, et al. Cell, 2008 Mar 7. PMID 18329365

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables taste receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemosensory behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to L-canavanine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to insecticide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    gustatory receptor 8a
    Names
    CG15371-PA
    Gr8a-PA
    gustatory receptor 8D1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9227137..9228827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078542.6 → NP_511097.3  gustatory receptor 8a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511097.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QF1, Q9W367
      Related
      FBpp0071246
      Conserved Domains (1) summary
      pfam08395
      Location:9 → 376
      7tm_7; 7tm Chemosensory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W367.1 Q9W367

    Gene LinkOut

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