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    Gs2 Glutamine synthetase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gs2provided by FlyBase
    Official Full Name
    Glutamine synthetase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0001145
    Locus tag
    Dmel_CG1743
    See related
    AllianceGenome:FB:FBgn0001145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1743; Dmel\CG1743; DmGS2; gs-c; gs2; GS2; GsII
    Summary
    Enables glutamine synthetase activity. Involved in glutamate catabolic process and synapse assembly. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; epithelium; ganglia; glial cell; and synaptic neuropil domain. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in congenital glutamine deficiency; epilepsy (multiple); heart disease; and neurodegenerative disease (multiple). Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Gs2 in Genome Data Viewer
    Location:
    10B11-10B11; 1-34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11422832..11430197)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11316865..11324230)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 10b Neighboring gene Odorant receptor 10a Neighboring gene Gustatory receptor 10a Neighboring gene Ecotropic viral integration site 5 Neighboring gene Sphingosine kinase 1 Neighboring gene Heterochromatin protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2. Chen WT, et al. Biomolecules, 2020 Dec 14. PMID 33327463, Free PMC Article
    2. A Distinct Perisynaptic Glial Cell Type Forms Tripartite Neuromuscular Synapses in the Drosophila Adult. Strauss AL, et al. PLoS One, 2015. PMID 26053860, Free PMC Article
    3. Homologous nuclear genes encode cytoplasmic and mitochondrial glutamine synthetase in Drosophila melanogaster. Caizzi R, et al. J Mol Biol, 1990 Mar 5. PMID 1969491
    4. Purification of the glutamine synthetase II isozyme of Drosophila melanogaster and structural and functional comparison of glutamine synthetases I and II. De Pinto V, et al. Biochem Genet, 1987 Dec. PMID 2897195
    5. Amyloid Precursor Protein in Drosophila Glia Regulates Sleep and Genes Involved in Glutamate Recycling. Farca Luna AJ, et al. J Neurosci, 2017 Apr 19. PMID 28314820, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2.
      Title: Structural Insight into the Contributions of the N-Terminus and Key Active-Site Residues to the Catalytic Efficiency of Glutamine Synthetase 2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamine synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine synthetase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamine synthetase 2
    Names
    CG1743-PA
    CG1743-PB
    CG1743-PC
    CG1743-PD
    CG1743-PE
    CG1743-PF
    Glutamate-ammonia ligase
    Gs2-PA
    Gs2-PB
    Gs2-PC
    Gs2-PD
    Gs2-PE
    Gs2-PF
    cytoplasmic glutamine synthetase
    glutamine synthase 2
    glutamine synthetase
    NP_001285121.1
    NP_001285122.1
    NP_001285123.1
    NP_511123.2
    NP_727525.1
    NP_996408.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11422832..11430197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298192.1 → NP_001285121.1  glutamine synthetase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV58, X2JDA5
      Conserved Domains (1) summary
      PLN02284
      Location:27 → 372
      PLN02284; glutamine synthetase

    2. NM_167284.2 → NP_727525.1  glutamine synthetase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727525.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV58, Q494K4
      Related
      FBpp0073344
      Conserved Domains (1) summary
      PLN02284
      Location:23 → 368
      PLN02284; glutamine synthetase

    3. NM_001298194.1 → NP_001285123.1  glutamine synthetase 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285123.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20478, Q8IR90, Q95SM4, Q9VYZ0
      UniProtKB/TrEMBL
      C8VV58, X2JJG8
      Conserved Domains (1) summary
      PLN02284
      Location:23 → 368
      PLN02284; glutamine synthetase

    4. NM_001298193.1 → NP_001285122.1  glutamine synthetase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285122.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20478, Q8IR90, Q95SM4, Q9VYZ0
      UniProtKB/TrEMBL
      C8VV58, X2JJG8
      Conserved Domains (1) summary
      PLN02284
      Location:23 → 368
      PLN02284; glutamine synthetase

    5. NM_206685.2 → NP_996408.1  glutamine synthetase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996408.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20478
      Conserved Domains (1) summary
      pfam00120
      Location:28 → 259
      Gln-synt_C; Glutamine synthetase, catalytic domain

    6. NM_078568.3 → NP_511123.2  glutamine synthetase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511123.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20478, Q8IR90, Q95SM4, Q9VYZ0
      UniProtKB/TrEMBL
      C8VV58, X2JJG8
      Related
      FBpp0073345
      Conserved Domains (1) summary
      PLN02284
      Location:23 → 368
      PLN02284; glutamine synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20478.3 P20478
    X2JDA5 X2JDA5
    X2JJG8 X2JJG8

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