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    eIF4H1 eukaryotic translation initiation factor 4H1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eIF4H1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4H1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262734
    Locus tag
    Dmel_CG4429
    See related
    AllianceGenome:FB:FBgn0262734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1B9; cg4429; CG4429; Dmel\CG4429; eIF4H; EIF4H1; MRE9; Rbp2; RNA-binding protein 2; rrm2; RRM2
    Summary
    Predicted to enable mRNA binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF4H1 in Genome Data Viewer
    Location:
    14C6-14C8; 1-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16448665..16454972)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16342698..16349005)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit alpha Neighboring gene rings lost Neighboring gene uncharacterized protein Neighboring gene paralytic Neighboring gene Calnexin 14D Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxicity of pathogenic ataxin-2 in Drosophila shows dependence on a pure CAG repeat sequence. McGurk L, et al. Hum Mol Genet, 2021 Sep 15. PMID 34077532, Free PMC Article
    2. Role for para sodium channel gene 3' UTR in the modification of Drosophila seizure susceptibility. Song J, et al. Dev Neurobiol, 2007 Dec. PMID 17918245
    3. Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. Parker L, et al. Genetics, 2011 Feb. PMID 21115970, Free PMC Article
    4. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Goodman LD, et al. Acta Neuropathol Commun, 2019 Apr 25. PMID 31023341, Free PMC Article
    5. DDX3X and specific initiation factors modulate FMR1 repeat-associated non-AUG-initiated translation. Linsalata AE, et al. EMBO Rep, 2019 Sep. PMID 31347257, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4H1
    Names
    CG4429-PA
    CG4429-PB
    CG4429-PC
    CG4429-PD
    CG4429-PE
    RNA-binding protein 2
    anon-fast-evolving-1B9
    eIF4H1-PA
    eIF4H1-PB
    eIF4H1-PC
    eIF4H1-PD
    eIF4H1-PE
    mRNA-like ncRNA in embryogenesis 9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16448665..16454972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080220.5 → NP_524959.1  eukaryotic translation initiation factor 4H1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH88, Q9VXF8
      Related
      FBpp0074055
      Conserved Domains (3) summary
      COG0724
      Location:19 → 224
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam05091
      Location:173 → 235
      eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
      cl17169
      Location:28 → 106
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_167522.5 → NP_727982.1  eukaryotic translation initiation factor 4H1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH88, Q8IR13
      Related
      FBpp0074056
      Conserved Domains (3) summary
      COG0724
      Location:18 → 223
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam05091
      Location:172 → 234
      eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
      cl17169
      Location:27 → 105
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001298401.1 → NP_001285330.1  eukaryotic translation initiation factor 4H1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R50, X2JC79
      Conserved Domains (2) summary
      COG0724
      Location:19 → 139
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12401
      Location:28 → 106
      RRM_eIF4H; RNA recognition motif in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins

    4. NM_206764.3 → NP_996487.1  eukaryotic translation initiation factor 4H1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R50, Q7KUX7
      Conserved Domains (2) summary
      COG0724
      Location:19 → 139
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:28 → 106
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001298402.1 → NP_001285331.1  eukaryotic translation initiation factor 4H1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH88, X2JE34
      Conserved Domains (3) summary
      COG0724
      Location:11 → 216
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam05091
      Location:165 → 227
      eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
      cl17169
      Location:20 → 98
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q26272 Q26272
    Q7KUX7 Q7KUX7
    Q8IR13 Q8IR13
    Q9VXF8 Q9VXF8
    X2JC79 X2JC79
    X2JE34 X2JE34

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