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    Nt5b 5' nucleotidase B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5bprovided by FlyBase
    Official Full Name
    5' nucleotidase Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052549
    Locus tag
    Dmel_CG32549
    See related
    AllianceGenome:FB:FBgn0052549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    24643014; 24643016; 45555989; 45555998; CG32549; CG6247; CG6267; CG6278; Dmel\CG32549; dNT5B
    Summary
    Predicted to enable 5'-nucleotidase activity. Predicted to be involved in adenosine metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic epipharynx; and embryonic hypopharynx. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to several human genes including NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nt5b in Genome Data Viewer
    Location:
    17A10-17A11; 1-60 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18390498..18410144, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18284531..18304177, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) beta Neighboring gene Transferrin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells. Duarte RRR, et al. Biol Psychiatry, 2019 Jul 15. PMID 31097295, Free PMC Article
    2. Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr). Singgih EL, et al. Transl Psychiatry, 2021 Jan 18. PMID 33462198, Free PMC Article
    3. Fat body-specific reduction of CTPS alleviates HFD-induced obesity. Liu J, et al. Elife, 2023 Sep 11. PMID 37695169, Free PMC Article
    4. A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses. Baranski TJ, et al. PLoS Genet, 2018 Apr. PMID 29608557, Free PMC Article
    5. Minos as a genetic and genomic tool in Drosophila melanogaster. Metaxakis A, et al. Genetics, 2005 Oct. PMID 15972463, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5' nucleotidase B
    Names
    CG32549-PB
    CG32549-PD
    CG32549-PE
    CG32549-PF
    CG32549-PG
    CG32549-PH
    Nt5b-PB
    Nt5b-PD
    Nt5b-PE
    Nt5b-PF
    Nt5b-PG
    Nt5b-PH
    NP_573289.2
    NP_728162.1
    NP_728163.2
    NP_996508.1
    NP_996509.1
    NP_996510.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18390498..18410144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133061.3 → NP_573289.2  5' nucleotidase B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573289.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K571, Q9VWV2, Q9VWV3
      Related
      FBpp0074342
      Conserved Domains (1) summary
      pfam05761
      Location:37 → 482
      5_nucleotid; 5' nucleotidase family

    2. NM_206785.2 → NP_996508.1  5' nucleotidase B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG9, Q7KUW2
      Conserved Domains (1) summary
      pfam05761
      Location:68 → 513
      5_nucleotid; 5' nucleotidase family

    3. NM_206786.2 → NP_996509.1  5' nucleotidase B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG9, Q7KUW2
      Conserved Domains (1) summary
      pfam05761
      Location:68 → 513
      5_nucleotid; 5' nucleotidase family

    4. NM_167614.2 → NP_728162.1  5' nucleotidase B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K571, Q9VWV4
      Related
      FBpp0074343
      Conserved Domains (1) summary
      pfam05761
      Location:86 → 531
      5_nucleotid; 5' nucleotidase family

    5. NM_167615.2 → NP_728163.2  5' nucleotidase B, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728163.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG9, Q7KUW3, Q961R1, Q9VWV5
      Conserved Domains (1) summary
      pfam05761
      Location:165 → 610
      5_nucleotid; 5' nucleotidase family

    6. NM_206787.2 → NP_996510.2  5' nucleotidase B, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996510.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0IQG9, Q7KUW3, Q961R1, Q9VWV5
      Conserved Domains (1) summary
      pfam05761
      Location:165 → 610
      5_nucleotid; 5' nucleotidase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K571 Q7K571
    Q7KUW2 Q7KUW2
    Q9VWV2 Q9VWV2
    Q9VWV4 Q9VWV4
    Q9VWV5 Q9VWV5

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