Dop2R Dopamine 2-like receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dop2Rprovided by FlyBase
Official Full Name: Dopamine 2-like receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0053517
Locus tag: Dmel_CG33517
See related: AllianceGenome:FB:FBgn0053517
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.130; anon-WO0170980.131; anon-WO0170980.31; anon-WO0170980.32; CG17004; CG33517; CG9569; d2r; D2R; dD2R; DD2R; DmDOP3; Dmel\CG33517; Dop2r
Summary: Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in G protein-coupled dopamine receptor signaling pathway and anesthesia-resistant memory. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult deutocerebrum; anterior-posterior subdivision of organism; embryonic/larval anterior Malpighian tubule; ganglia; and gut section. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; movement disease (multiple); and nicotine dependence. Orthologous to several human genes including DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 19A4-19A6; 1-64 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (20004680..20062706, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19898713..19956739, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the same group of dopaminergic neurons also form functional synaptic connections with the anterior paired lateral neurons, thereby emitting a suppressive signal to the latter through Drosophila dopamine 2-like receptor.
Title: Suppression of GABAergic neurons through D2-like receptor secures efficient conditioning in Drosophila aversive olfactory learning.
By means of genetic mosaicism, we identified widespread dopaminergic modulation within the olfactory circuit that suggests nonredundant and reiterating functions of D2R in support of ARM. Our results oppose ARM to its concomitant memory phases that localize to mushroom bodies and propose a decentralized organization of consolidated ARM.
Title: Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory.
The results suggest that fruit flies are an excellent model system to provide some answers to previously unexplainable observations regarding the compromised dopaminergic nervous system and the related therapeutic agents.
Title: Dopamine D2 receptor as a cellular component controlling nocturnal hyperactivities in Drosophila melanogaster.
Our study also showed that rescue of dopaminergic (DA) neurodegeneration by Drosophila DD2R activation was mediated through suppression of action potentials in DA neurons.
Title: Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture.
It is concluded that the change in the number of DD2Rs in corpus allatum or their activation decreases the fitness of Drosophila.
Title: [The DD2R gene expression level in the corpus allatum affects the fitness of female Drosophila melanogaster].
mediates, at least in part, the inhibiting effect of dopamine on juvenile hormone synthesis
Title: Downregulation of the dopamine D2-like receptor in corpus allatum affects juvenile hormone synthesis in Drosophila melanogaster females.
role of DD2R in the regulation of juvenile hormone metabolism
Title: The role of D2-like receptors in the regulation of juvenile hormone metabolism in Drosophila females in normal state and at increased dopamine level.
Alkaline phosphatase activity was increased in flies with reduced DD2R expression vs. corresponding controls.
Title: Dopamine down-regulates activity of alkaline phosphatase in Drosophila: the role of D2-like receptors.
Data show that activation of D2-like dopamine receptors inhibits juvenile hormone degradation in female Drosophila.
Title: Activation of D2-like dopamine receptors inhibits young hormone degradation in female Drosophila.
Locomotor activity is regulated by D2-like receptors in Drosophila
Title: Locomotor activity is regulated by D2-like receptors in Drosophila: an anatomic and functional analysis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0488 (e-PCR)
- UniSTS:59317

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c20060775-20060725 mobile_element_type = transposon:INE-1{}4836

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in anesthesia-resistant memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dopamine 2-like receptor

Names: CG33517-PB; CG33517-PF; CG33517-PG; CG33517-PH; CG33517-PI; CG33517-PJ; D2 autoreceptor; D2-like receptor; D[[2]] receptor; D[[2]]-like receptor; Dop2R-PB; Dop2R-PF; Dop2R-PG; Dop2R-PH; Dop2R-PI; Dop2R-PJ; dopamine D2 receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

20004680..20062706 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298548.1 → NP_001285477.1 dopamine 2-like receptor, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285477.1

Status: REVIEWED

Conserved Domains (2) summary

pfam00001
Location:392 → 571

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:387 → 569

7tm_4; Olfactory receptor
NM_001014757.3 → NP_001014757.2 dopamine 2-like receptor, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014757.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IS44

Conserved Domains (2) summary

pfam00001
Location:392 → 742

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:387 → 569

7tm_4; Olfactory receptor
NM_001031909.2 → NP_001027080.2 dopamine 2-like receptor, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027080.2

Status: REVIEWED

Conserved Domains (2) summary

pfam00001
Location:392 → 787

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:387 → 569

7tm_4; Olfactory receptor
NM_001014760.3 → NP_001014760.2 dopamine 2-like receptor, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014760.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IS44

Conserved Domains (3) summary

cd15053
Location:376 → 565

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:827 → 849

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:821 → 897

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001014758.3 → NP_001014758.2 dopamine 2-like receptor, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014758.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4ABK5, Q59E80, Q59E81, Q59E82, Q6AWL2, Q8IS43, Q8IS44, Q8IS45, Q9W5X7, Q9W5X8, X2JLE1

Conserved Domains (3) summary

cd14964
Location:825 → 850

7tm_GPCRs; TM helix 6 [structural motif]

cd15053
Location:376 → 565

7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cl28897
Location:822 → 898

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001014759.2 → NP_001014759.1 dopamine 2-like receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014759.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IS44

Conserved Domains (2) summary

pfam00001
Location:6 → 140

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:365 → 463

7tm_4; Olfactory receptor