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    GstT3 Glutathione S transferase T3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33047, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstT3provided by FlyBase
    Official Full Name
    Glutathione S transferase T3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031117
    Locus tag
    Dmel_CG1702
    See related
    AllianceGenome:FB:FBgn0031117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg1702; CG1702; Dmel\CG1702; DmGSTT3a; DmGSTT3b; gstt3; GSTT3; GSTT3a; GSTT3b
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult midgut progenitor cell; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstT3 in Genome Data Viewer
    Location:
    19D1-19D1; 1-64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20467455..20469796)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20338482..20340823)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene trabuco Neighboring gene Rho GTPase activating protein at 19D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Callebaut I, et al. Trends Biochem Sci, 2001 Feb. PMID 11166556
    2. Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation in Drosophila. Lv M, et al. Nucleic Acids Res, 2019 Apr 8. PMID 30649456, Free PMC Article
    3. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article
    4. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Li HM, et al. Insect Mol Biol, 2010 Jun 1. PMID 20113373
    5. Coordinated regulation of heterochromatic genes in Drosophila melanogaster males. Deng X, et al. Genetics, 2009 Jun. PMID 19307603, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase T3
    Names
    CG1702-PA
    CG1702-PB
    CG1702-PC
    GstT3-PA
    GstT3-PB
    GstT3-PC
    NP_001162808.1
    NP_001285495.1
    NP_728347.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20467455..20469796
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298566.1 → NP_001285495.1  glutathione S transferase T3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZE4, Q9VRA4
      Conserved Domains (3) summary
      cd03183
      Location:95 → 219
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      COG0625
      Location:7 → 203
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:5 → 81
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    2. NM_001169337.2 → NP_001162808.1  glutathione S transferase T3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DMK8, E1JJS1
      Conserved Domains (3) summary
      cd03183
      Location:135 → 259
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      COG0625
      Location:47 → 243
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:45 → 121
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    3. NM_167706.3 → NP_728347.1  glutathione S transferase T3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZE4, Q9VRA4
      Related
      FBpp0077002
      Conserved Domains (3) summary
      cd03183
      Location:95 → 219
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      COG0625
      Location:7 → 203
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:5 → 81
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJS1 E1JJS1
    Q8SZE4 Q8SZE4
    Q9VRA4 Q9VRA4

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