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    MED31 Mediator complex subunit 31 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED31provided by FlyBase
    Official Full Name
    Mediator complex subunit 31provided by FlyBase
    Primary source
    FLYBASE:FBgn0037262
    Locus tag
    Dmel_CG1057
    See related
    AllianceGenome:FB:FBgn0037262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM28912; CG1057; Dmel\CG1057; dSOH1; dTRAP18; med31; Med31; p36; Trap18
    Summary
    Contributes to transcription coactivator activity. Involved in anterior/posterior axis specification, embryo and regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in organism. Orthologous to human MED31 (mediator complex subunit 31). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED31 in Genome Data Viewer
    Location:
    82C5-82C5; 3-47.1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4641963..4643292)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (467685..469014)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45673 Neighboring gene uncharacterized protein Neighboring gene stable intronic sequence RNA CR46358 Neighboring gene nuclease slx1 Neighboring gene Dorsal interacting protein 2 Neighboring gene antisense RNA:CR44155 Neighboring gene ripped pocket

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila. Andersen SL, et al. PLoS Genet, 2011 Oct. PMID 22022278, Free PMC Article
    2. Imp and Syp mediated temporal patterning of neural stem cells in the developing Drosophila CNS. Islam IM, et al. Genetics, 2022 Aug 30. PMID 35881070, Free PMC Article
    3. Imp and Syp RNA-binding proteins govern decommissioning of Drosophila neural stem cells. Yang CP, et al. Development, 2017 Oct 1. PMID 28851709, Free PMC Article
    4. Two subunits of the Drosophila mediator complex act together to control cell affinity. Janody F, et al. Development, 2003 Aug. PMID 12835386
    5. Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31. Bosveld F, et al. Dev Biol, 2008 Jan 15. PMID 18083158

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 31
    Names
    CG1057-PA
    CG1057-PB
    CG1057-PC
    CG1057-PD
    CG1057-PE
    MED31-PA
    MED31-PB
    MED31-PC
    MED31-PD
    MED31-PE
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4641963..4643292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141226.4 → NP_649483.1  mediator complex subunit 31, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2E4, Q8IH24, Q9VN40
      UniProtKB/TrEMBL
      A0A0B4K6R3
      Related
      FBpp0078496
      Conserved Domains (1) summary
      pfam05669
      Location:19 → 112
      Med31; SOH1

    2. NM_001275329.1 → NP_001262258.1  mediator complex subunit 31, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG28
      Conserved Domains (1) summary
      pfam05669
      Location:17 → 110
      Med31; SOH1

    3. NM_169013.3 → NP_730861.1  mediator complex subunit 31, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2E4, Q8IH24, Q9VN40
      UniProtKB/TrEMBL
      A0A0B4K6R3
      Related
      FBpp0078497
      Conserved Domains (1) summary
      pfam05669
      Location:19 → 112
      Med31; SOH1

    4. NM_001259979.2 → NP_001246908.1  mediator complex subunit 31, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2E4, Q8IH24, Q9VN40
      UniProtKB/TrEMBL
      A0A0B4K6R3
      Conserved Domains (1) summary
      pfam05669
      Location:19 → 112
      Med31; SOH1

    5. NM_001300230.1 → NP_001287159.1  mediator complex subunit 31, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGM8
      Conserved Domains (1) summary
      pfam05669
      Location:14 → 107
      Med31; SOH1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6R3 A0A0B4K6R3
    A0A0B4KG28 A0A0B4KG28
    A0A0B4LGM8 A0A0B4LGM8
    Q8IH24.2 Q8IH24

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