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    Syt4 Synaptotagmin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40876, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Syt4provided by FlyBase
    Official Full Name
    Synaptotagmin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0028400
    Locus tag
    Dmel_CG10047
    See related
    AllianceGenome:FB:FBgn0028400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10047; D.Syt IV; Dmel\CG10047; dsyt4; syt 4; Syt IV; syt4; SYT4; sytIV; SytIV
    Summary
    Enables SNARE binding activity; calcium-dependent phospholipid binding activity; and phosphatidylserine binding activity. Involved in positive regulation of vesicle fusion; regulation of neurotransmitter secretion; and regulation of synaptic plasticity. Located in several cellular components, including apical plasma membrane; neuromuscular junction; and postsynaptic membrane. Is expressed in several structures, including adult head; embryonic head sensory system; embryonic midline of ventral nerve cord; ganglia; and sensory nervous system primordium. Orthologous to human SYT11 (synaptotagmin 11) and SYT4 (synaptotagmin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Syt4 in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7266065..7270809)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3091787..3096531)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene DTW domain containing 2 Neighboring gene Odorant-binding protein 84a Neighboring gene Glucose dehydrogenase Neighboring gene long non-coding RNA:CR44338 Neighboring gene pseudo Neighboring gene rotund Neighboring gene long non-coding RNA:CR44333

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of synaptotagmin in Ca2+-triggered exocytosis. Tucker WC, et al. Biochem J, 2002 Aug 15. PMID 12047220, Free PMC Article
    2. Regulated Alternative Splicing of Drosophila Dscam2 Is Necessary for Attaining the Appropriate Number of Photoreceptor Synapses. Kerwin SK, et al. Genetics, 2018 Feb. PMID 29208630, Free PMC Article
    3. Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain. Robinson IM, et al. Nature, 2002 Jul 18. PMID 12110845
    4. Characterization of the role of the Synaptotagmin family as calcium sensors in facilitation and asynchronous neurotransmitter release. Saraswati S, et al. Proc Natl Acad Sci U S A, 2007 Aug 28. PMID 17709738, Free PMC Article
    5. Regulation of postsynaptic retrograde signaling by presynaptic exosome release. Korkut C, et al. Neuron, 2013 Mar 20. PMID 23522040, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic interaction experiments demonstrate Syx4, Syt4, and Nlg1 regulate synaptic growth and plasticity through both shared and parallel signaling pathways.
      Title: The postsynaptic t-SNARE Syntaxin 4 controls traffic of Neuroligin 1 and Synaptotagmin 4 to regulate retrograde signaling.
    2. A retrograde signal mediated by Synaptotagmin 4 is transmitted to the postsynaptic cell through anterograde delivery of Synaptotagmin 4 via exosomes.
      Title: Regulation of postsynaptic retrograde signaling by presynaptic exosome release.
    3. Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.
      Title: Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.
    4. Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 as a Ca(2+) sensor for presynaptic vesicle fusion.
      Title: Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.
    5. Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain
      Title: Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain.
    6. results demonstrate that acute plasticity and synapse-specific growth require Syt 4-dependent retrograde signaling at Drosophila neuromuscular junctions
      Title: Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables phosphatidylserine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptotagmin 4
    Names
    CG10047-PA
    Syt4-PA
    synaptotagmin IV

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7266065..7270809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058116.5 → NP_477464.1  synaptotagmin 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477464.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYD5, Q9U6P7, Q9VI88
      Related
      FBpp0081097
      Conserved Domains (2) summary
      cd08388
      Location:179 → 322
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:332 → 473
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYD5 Q8SYD5
    Q9U6P7 Q9U6P7

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