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    Nup43 Nucleoporin 43kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup43provided by FlyBase
    Official Full Name
    Nucleoporin 43kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038609
    Locus tag
    Dmel_CG7671
    See related
    AllianceGenome:FB:FBgn0038609
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7671; Dmel\CG7671; nup43
    Summary
    Involved in mitotic cell cycle. Predicted to be part of nuclear pore outer ring. Is expressed in organism. Used to study candidiasis. Orthologous to human NUP43 (nucleoporin 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nup43 in Genome Data Viewer
    Location:
    91A3-91A3; 3-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18366638..18367913)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14192360..14193635)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45634 Neighboring gene hemingway Neighboring gene WRN exonuclease Neighboring gene glass Neighboring gene long non-coding RNA:CR14310

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Bub3 and Nup75 in the Drosophila male germline lineage. Yildirim K, et al. Cells Dev, 2023 Sep. PMID 37286104
    2. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. Anderson EN, et al. Elife, 2021 May 26. PMID 34060470, Free PMC Article
    3. Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Lin YC, et al. Nat Neurosci, 2021 Aug. PMID 34059832, Free PMC Article
    4. Functional genomics evidence unearths new moonlighting roles of outer ring coat nucleoporins. Katsani KR, et al. Sci Rep, 2014 Apr 11. PMID 24722254, Free PMC Article
    5. Genetic Analyses of Elys Mutations in Drosophila Show Maternal-Effect Lethality and Interactions with Nucleoporin Genes. Hirai K, et al. G3 (Bethesda), 2018 Jul 2. PMID 29773558, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle HMP PubMed 
    Component Evidence Code Pubs
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin 43kD
    Names
    CG7671-PA
    Nup43-PA
    nucleoporin 43

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18366638..18367913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142459.4 → NP_650716.2  nucleoporin 43kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650716.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJQ1, Q9VE85
      Related
      FBpp0082998
      Conserved Domains (3) summary
      COG2319
      Location:142 → 344
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:16 → 73
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:74 → 347
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYC6 Q8SYC6
    Q9VE85 Q9VE85

    Gene LinkOut

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