Syx1A Syntaxin 1A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Syx1Aprovided by FlyBase
Official Full Name: Syntaxin 1Aprovided by FlyBase
Primary source: FLYBASE:FBgn0013343
Locus tag: Dmel_CG31136
See related: AllianceGenome:FB:FBgn0013343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Gibbs4; anon-WO02059370.54; CG10716; CG18615; CG31136; CG5448; CT30033; Dm Syx1; Dmel\CG31136; DmSyx1A; dsyn-1A; dSyx1; l(3)06737; STX1; Stx1a; Sx1A; Syn; synt; syntaxin; syntaxin1A; Synx1A; syt-1A; Syt1A; sytx; syx; Syx; SYX; SYX 1A; syx-1; syx-1A; Syx-1A; syx1; Syx1; syx1A; Syx1a; SYX1A; SyxA
Summary: Enables SNAP receptor activity and SNARE binding activity. Involved in several processes, including haltere development; neuromuscular synaptic transmission; and secretion by cell. Located in synaptic vesicle and terminal bouton. Part of SNARE complex. Is expressed in several structures, including brain; embryonic/larval midgut primordium; germ layer; gut section; and neuromuscular junction. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Hirschsprung's disease; congenital diarrhea; and generalized epilepsy with febrile seizures plus 9. Orthologous to several human genes including STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95E1-95E1; 3-83 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24101600..24105763, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19927322..19931485, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin 1 Ser[14] phosphorylation is required for nonvesicular dopamine release.
Title: Syntaxin 1 Ser(14) phosphorylation is required for nonvesicular dopamine release.
Syntaxin1A plays a key role in neurotransmission, presenting a crucial endpoint for synaptic vesicle release, without which neurotransmission could not occur.
Title: Syntaxin1A Neomorphic Mutations Promote Rapid Recovery from Isoflurane Anesthesia in Drosophila melanogaster.
The data demonstrate that polyphosphoinositide favors syntaxin1A trapping, and show that SNARE complex disassembly leads to syntaxin1A dissociation from presynaptic nanoclusters.
Title: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters.
The authors found two syntaxin1A mutations that confer opposite general anesthesia phenotypes
Title: Syntaxin1A-mediated Resistance and Hypersensitivity to Isoflurane in Drosophila melanogaster.
Data suggest that Ca(2+)-CaM regulation of V100 may control SNARE complex assembly for a subset of synaptic vesicles that sustain spontaneous release.
Title: Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1.
these results indicate that SNAP-25-R206 and syntaxin-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE complexes interacting via the ionic couple formed by these two residues.
Title: Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction.
Syntaxin1A domain formation is induced by phosphoinositide-3,4,5-triphosphate; this clustering is dependent on positively charged residues in the juxtamembrane domain.
Title: Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release.
The Syx1A dependent trafficking of Grk protein is required for efficient EGFR signaling during dorsal-ventral patterning.
Title: Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.
Syntaxin 1A molecules share a conserved threonine in C-terminal +7 layer near transmembrane domain. Mutation of threonine to isoleucine results in a structural change that resembles those found in syntaxins ascribed to the constitutive secretory pathway
Title: Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion.
analysis of epistatic interactions related to mutation of Syx1A
Title: Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0249 (e-PCR)
- UniSTS:79255

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNAP receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables SNAP receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellularization	TAS Traceable Author Statement more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in haltere development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretion of lysosomal enzymes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle docking	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle fusion to presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syntaxin 1A

Names: CG31136-PA; CG31136-PB; CG31136-PC; STX1A; Syx1A-PA; Syx1A-PB; Syx1A-PC; dsyntaxin-1A; synataxin 1; syntaxin; syntaxin 1; syntaxin-1; syntaxin-1A; syntaxin1; syntaxin1A; syntx 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24101600..24105763 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202347.2 → NP_001189276.1 syntaxin 1A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189276.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCZ4

Conserved Domains (2) summary

pfam00804
Location:33 → 230

Syntaxin

pfam05739
Location:231 → 281

SNARE; SNARE domain
NM_001316616.1 → NP_001303545.1 syntaxin 1A, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24547, Q9TX14, Q9VCD7

UniProtKB/TrEMBL

A0A126GV04

Conserved Domains (2) summary

pfam00804
Location:33 → 230

Syntaxin

pfam05739
Location:231 → 281

SNARE; SNARE domain
NM_079751.5 → NP_524475.1 syntaxin 1A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524475.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24547, Q9TX14, Q9VCD7

UniProtKB/TrEMBL

A0A126GV04

Related

FBpp0083973

Conserved Domains (2) summary

pfam00804
Location:33 → 230

Syntaxin

pfam05739
Location:231 → 281

SNARE; SNARE domain