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    Bili Band4.1 inhibitor LRP interactor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Biliprovided by FlyBase
    Official Full Name
    Band4.1 inhibitor LRP interactorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039282
    Locus tag
    Dmel_CG11848
    See related
    AllianceGenome:FB:FBgn0039282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11848; dBili; Dmel\CG11848
    Summary
    Involved in negative regulation of canonical Wnt signaling pathway. Colocalizes with plasma membrane. Is expressed in several structures, including anlage in statu nascendi; epithelium; ganglia; head epidermis primordium; and imaginal disc. Orthologous to human FRMD8 (FERM domain containing 8) and FRMD8P1 (FERM domain containing 8 pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bili in Genome Data Viewer
    Location:
    96C1-96C1; 3-87 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25131306..25136709)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20957028..20962431)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Molybdenum cofactor synthesis 2B Neighboring gene Molybdenum cofactor synthesis 2A Neighboring gene Caliban Neighboring gene long non-coding RNA:CR46098 Neighboring gene distal antenna-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. Kategaya LS, et al. PLoS One, 2009 Jul 2. PMID 19572019, Free PMC Article
    2. Birth of a new gene on the Y chromosome of Drosophila melanogaster. Carvalho AB, et al. Proc Natl Acad Sci U S A, 2015 Oct 6. PMID 26385968, Free PMC Article
    3. Distal antenna and distal antenna related encode nuclear proteins containing pipsqueak motifs involved in antenna development in Drosophila. Emerald BS, et al. Development, 2003 Mar. PMID 12571108
    4. Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia. Serio AW, et al. Cell Host Microbe, 2010 May 20. PMID 20478540, Free PMC Article
    5. Drosophila, an emerging model for cardiac disease. Bier E, et al. Gene, 2004 Nov 10. PMID 15527959

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Band4.1 inhibitor LRP interactor
    Names
    Bili-PB
    Bili-PC
    Bili-PD
    Bili-PE
    Bili-PF
    Bili-PG
    Bili-PH
    CG11848-PB
    CG11848-PC
    CG11848-PD
    CG11848-PE
    CG11848-PF
    CG11848-PG
    CG11848-PH
    band 4.1 FERM-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25131306..25136709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143085.3 → NP_651342.3  Band4.1 inhibitor LRP interactor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651342.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain

    2. NM_001170253.2 → NP_001163724.1  Band4.1 inhibitor LRP interactor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain

    3. NM_001170254.2 → NP_001163725.1  Band4.1 inhibitor LRP interactor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain

    4. NM_001170251.2 → NP_001163722.1  Band4.1 inhibitor LRP interactor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain

    5. NM_001170252.2 → NP_001163723.1  Band4.1 inhibitor LRP interactor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain

    6. NM_001300592.1 → NP_001287521.1  Band4.1 inhibitor LRP interactor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287521.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain

    7. NM_001170255.1 → NP_001163726.1  Band4.1 inhibitor LRP interactor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163726.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNK3, Q8SX93, Q9VBX0
      Conserved Domains (2) summary
      smart00295
      Location:432 → 663
      B41; Band 4.1 homologues
      pfam00373
      Location:539 → 663
      FERM_M; FERM central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBX0 Q9VBX0

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