VhaAC45RP VhaAC45-related protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: VhaAC45RPprovided by FlyBase
Official Full Name: VhaAC45-related proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0051030
Locus tag: Dmel_CG31030
See related: AllianceGenome:FB:FBgn0051030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey81; BcDNA:RH09162; CG2176; CG31030; Dmel\CG31030
Summary: Enables ATPase regulator activity. Involved in synaptic vesicle lumen acidification. Located in presynaptic membrane. Part of proton-transporting V-type ATPase complex. Is expressed in adult head; central brain primordium; embryonic antennal sense organ; ganglia; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30164692..30166419, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25990414..25992141, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

A Novel Neuron-Specific Regulator of the V-ATPase in Drosophila.
Title: A Novel Neuron-Specific Regulator of the V-ATPase in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of cellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting V-type ATPase complex	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain