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    CG9747 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9747provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039754
    Locus tag
    Dmel_CG9747
    See related
    AllianceGenome:FB:FBgn0039754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel MPSE; Dmel\CG9747
    Summary
    Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic dorsal apodeme; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD (stearoyl-CoA desaturase) and SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9747 in Genome Data Viewer
    Location:
    99E1-99E2; 3-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30185423..30191252, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26011145..26016974, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Blocked early in transport 5 Neighboring gene long non-coding RNA:CR44262 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic reprogramming of chromatin accessibility during Drosophila embryo development. Thomas S, et al. Genome Biol, 2011. PMID 21569360, Free PMC Article
    2. Molecular genetics and evolution of pheromone biosynthesis in Lepidoptera. Roelofs WL, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12876197, Free PMC Article
    3. Molecular Basis for Cephalic Mechanosensitivity of Drosophila Larvae. Zhang Z, et al. Neurosci Bull, 2020 Sep. PMID 32761438, Free PMC Article
    4. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Fortuna TR, et al. Acta Neuropathol, 2021 Sep. PMID 34061233, Free PMC Article
    5. Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Ambrus AM, et al. Genetics, 2009 Sep. PMID 19546319, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9747-PA
    CG9747-PB
    NP_001287604.1
    NP_651779.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30185423..30191252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300675.1 → NP_001287604.1  uncharacterized protein Dmel_CG9747, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA94
      Conserved Domains (2) summary
      cd03505
      Location:135 → 376
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:140 → 343
      FA_desaturase; Fatty acid desaturase

    2. NM_143522.4 → NP_651779.1  uncharacterized protein Dmel_CG9747, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651779.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA94
      Related
      FBpp0084939
      Conserved Domains (2) summary
      cd03505
      Location:135 → 376
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:140 → 343
      FA_desaturase; Fatty acid desaturase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA94 Q9VA94

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