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    Dro Drosocin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36635, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Droprovided by FlyBase
    Official Full Name
    Drosocinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010388
    Locus tag
    Dmel_CG10816
    See related
    AllianceGenome:FB:FBgn0010388
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    143609_at; BcDNA:RH31634; Btn; CG10816; DIM 11; DIM 15; DIM 9; DIM-15; Dmel\CG10816; drc; Drc; dro; Dro1; Droc; DROC; dros; Dros; drosocin; Drs; IM15; IM7
    Summary
    Involved in defense response to other organism and positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria. Located in extracellular region. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dro in Genome Data Viewer
    Location:
    51C1-51C1; 2-72 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14745961..14746714)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10633466..10634219)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jet fuel Neighboring gene Attacin-A Neighboring gene Attacin-B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substitution of the GalNAc-α-O-Thr¹¹ residue in drosocin with O-linked glyco-peptoid residue: effect on antibacterial activity and conformational change. Ahn M, et al. Bioorg Med Chem Lett, 2011 Oct 15. PMID 21890357
    2. Inhibition of translation termination by the antimicrobial peptide Drosocin. Mangano K, et al. Nat Chem Biol, 2023 Sep. PMID 36997647, Free PMC Article
    3. A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution. Bulet P, et al. J Biol Chem, 1993 Jul 15. PMID 8325867
    4. Enlarged scale chemical synthesis and range of activity of drosocin, an O-glycosylated antibacterial peptide of Drosophila. Bulet P, et al. Eur J Biochem, 1996 May 15. PMID 8665953
    5. Structural basis for translation inhibition by the glycosylated drosocin peptide. Koller TO, et al. Nat Chem Biol, 2023 Sep. PMID 36997646, Free PMC Article

    See all (318) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of translation termination by the antimicrobial peptide Drosocin.
      Title: Inhibition of translation termination by the antimicrobial peptide Drosocin.
    2. Structural basis for translation inhibition by the glycosylated drosocin peptide.
      Title: Structural basis for translation inhibition by the glycosylated drosocin peptide.
    3. Naturally occurring glycosylated forms of proline rich antibacterial peptide, drosocin, manifest structure-dependent antimicrobial activities.
      Title: Comparing naturally occurring glycosylated forms of proline rich antibacterial peptide, Drosocin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium HEP PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    drosocin
    Names
    CG10816-PA
    CG10816-PB
    Dro-PA
    Dro-PB
    Immune-induced molecule 7
    buletin
    drosocin (D)
    drosocin precursor
    drosophila immune induced molecule 11
    drosophila immune induced molecule 15
    drosophila immune induced molecule 9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14745961..14746714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259395.2 → NP_001246324.1  drosocin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36193, Q53ZZ5, Q867T5, Q86BV9, Q9V749
      UniProtKB/TrEMBL
      A0A0B4K7Q5

    2. NM_079020.5 → NP_523744.1  drosocin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523744.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36193, Q53ZZ5, Q867T5, Q86BV9, Q9V749
      UniProtKB/TrEMBL
      A0A0B4K7Q5
      Related
      FBpp0086566
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7Q5 A0A0B4K7Q5
    P36193.2 P36193

    Gene LinkOut

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