Gbp1 Growth-blocking peptide 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gbp1provided by FlyBase
Official Full Name: Growth-blocking peptide 1provided by FlyBase
Primary source: FLYBASE:FBgn0034199
Locus tag: Dmel_CG15917
See related: AllianceGenome:FB:FBgn0034199
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15917; Dmel\CG15917; Gbp; GBP; gbp1; GBP1
Summary: Enables cytokine activity. Involved in several processes, including positive regulation of antimicrobial peptide production; positive regulation of cell communication; and positive regulation of homotypic cell-cell adhesion. Predicted to be located in extracellular space. Is expressed in adult fat body; embryonic/larval Malpighian tubule; embryonic/larval fat body; embryonic/larval hemocyte; and larval integumentary system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17136451..17136903)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13023956..13024408)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

the metabolic, immunological, and stress-protecting roles of GBP all interconnect through Mthl10.
Title: Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.
Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP.
Title: Switching between humoral and cellular immune responses in Drosophila is guided by the cytokine GBP.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cytokine activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of humoral immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed