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    Gint3 GDI interacting protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gint3provided by FlyBase
    Official Full Name
    GDI interacting protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0034372
    Locus tag
    Dmel_CG5469
    See related
    AllianceGenome:FB:FBgn0034372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5469; Dmel\CG5469; Dromel_CG5469_FBtr0086654_gint3_mORF; UBX 6 like
    Summary
    Involved in positive regulation of canonical Wnt signaling pathway. Located in apical cortex. Is expressed in adult head; organism; and spermatozoon. Orthologous to human UBXN6 (UBX domain protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gint3 in Genome Data Viewer
    Location:
    55E5-55E5; 2-86 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18658418..18661548, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14545923..14549053, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chemosensory protein A 56a Neighboring gene N-terminal amidohydrolase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ETS-domain lacking

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    2. Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster. Takahara B, et al. PLoS One, 2015. PMID 26182199, Free PMC Article
    3. Diversification of heart progenitor cells by EGF signaling and differential modulation of ETS protein activity. Schwarz B, et al. Elife, 2018 Jun 5. PMID 29869981, Free PMC Article
    4. Protection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signaling. Reim G, et al. PLoS Biol, 2014 Nov. PMID 25369031, Free PMC Article
    5. Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes. Takahashi H, et al. Sci Rep, 2020 Oct 1. PMID 33004976, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GDI interacting protein 3
    Names
    CG5469-PB
    CG5469-PD
    CG5469-PE
    Gint3-PB
    Gint3-PD
    Gint3-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18658418..18661548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137512.3 → NP_611356.1  GDI interacting protein 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0S5
      Related
      FBpp0085836
      Conserved Domains (2) summary
      cd10460
      Location:171 → 268
      PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
      cl00155
      Location:341 → 414
      UBQ; Ubiquitin-like proteins

    2. NM_166301.2 → NP_725812.1  GDI interacting protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0S5
      Related
      FBpp0085837
      Conserved Domains (2) summary
      cd10460
      Location:171 → 268
      PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
      cl00155
      Location:341 → 414
      UBQ; Ubiquitin-like proteins

    3. NM_166302.2 → NP_725813.1  GDI interacting protein 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0S5
      Related
      FBpp0309338
      Conserved Domains (2) summary
      cd10460
      Location:171 → 268
      PUB_UBXD1; PNGase/UBA or UBX (PUB) domain of UBXD1
      cl00155
      Location:341 → 414
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0S5 Q7K0S5

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