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    rig rigor mortis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rigprovided by FlyBase
    Official Full Name
    rigor mortisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250850
    Locus tag
    Dmel_CG30149
    See related
    AllianceGenome:FB:FBgn0250850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-SAGE:Wang-132; CG11171; CG13440; CG30149; Dmel\CG30149; Gem5; Gemin5; l(2)05056; Rig
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Involved in flight behavior; molting cycle; and response to ecdysone. Located in cytoplasm and nucleus. Part of SMN complex and cytoplasmic U snRNP body. Is expressed in adult head; nurse cell; and oocyte. Used to study neurodevelopmental disorder with cerebellar atrophy and motor dysfunction. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cerebellar atrophy and motor dysfunction. Orthologous to human GEMIN5 (gem nuclear organelle associated protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rig in Genome Data Viewer
    Location:
    57A8-57A8; 2-91 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20633876..20640681, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16521381..16528186, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Family with sequence similarity 21 Neighboring gene Reduction in Cnn dots 6 Neighboring gene uncharacterized protein Neighboring gene maf-S Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit K Neighboring gene Threonyl-carbamoyl synthesis 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder. Kour S, et al. Nat Commun, 2021 May 7. PMID 33963192, Free PMC Article
    2. Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila. Borg RM, et al. PLoS One, 2015. PMID 26098872, Free PMC Article
    3. The Gemin associates of survival motor neuron are required for motor function in Drosophila. Borg R, et al. PLoS One, 2013. PMID 24391840, Free PMC Article
    4. U bodies respond to nutrient stress in Drosophila. Buckingham M, et al. Exp Cell Res, 2011 Dec 10. PMID 21939654
    5. Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Shpargel KB, et al. Mol Biol Cell, 2009 Jan. PMID 18923150, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dynamic intracellular redistribution of Rig protein suggests that it may act to refine spatial and temporal responses to ecdysone during development.
      Title: rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SMN complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SMN complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic U snRNP body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rigor mortis
    Names
    CG30149-PB
    Gemin5
    anon-SAGE:Wang-132
    rig-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20633876..20640681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137655.3 → NP_611499.3  rigor mortis [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611499.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86BY9, Q86P78, Q9V957
      Related
      FBpp0085564
      Conserved Domains (3) summary
      COG2319
      Location:434 → 821
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:617 → 654
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:613 → 874
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BY9.1 Q86BY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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