CG9485 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG9485provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0034618
Locus tag: Dmel_CG9485
See related: AllianceGenome:FB:FBgn0034618
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:GH22856; Dmel\CG9485
Summary: Predicted to enable 4-alpha-glucanotransferase activity and amylo-alpha-1,6-glucosidase activity. Predicted to be involved in glycogen catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; embryonic dorsal epidermis; and mesoderm. Human ortholog(s) of this gene implicated in glycogen storage disease III. Orthologous to human AGL (amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 57D11-57D11; 2-94 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21312399..21319569)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17199904..17207074)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 4-alpha-glucanotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-alpha-glucanotransferase activity	IEA Inferred from Electronic Annotation more info
enables 4-alpha-glucanotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables amylo-alpha-1,6-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amylo-alpha-1,6-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables amylo-alpha-1,6-glucosidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycogen debranching enzyme activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG9485-PA; CG9485-PB; CG9485-PC; CG9485-PD; CG9485-PE; CG9485-PF

NP_001163234.1

EC 2.4.1.25

EC 3.2.1.33

NP_001163235.1

EC 2.4.1.25

EC 3.2.1.33

NP_001261123.1

EC 2.4.1.25

EC 3.2.1.33

NP_611577.2

EC 2.4.1.25

EC 3.2.1.33

NP_726061.1

EC 2.4.1.25

EC 3.2.1.33

NP_726062.2

EC 2.4.1.25

EC 3.2.1.33

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21312399..21319569

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274194.2 → NP_001261123.1 uncharacterized protein Dmel_CG9485, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261123.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD6, Q7KVP4

Conserved Domains (6) summary

cd11327
Location:125 → 617

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:25 → 1534

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:1060 → 1529

GDE_C; Amylo-alpha-1,6-glucosidase

pfam14699
Location:34 → 137

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:723 → 993

hGDE_central; central domain of human glycogen debranching enzyme

cl10013
Location:989 → 1063

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NM_001169763.2 → NP_001163234.1 uncharacterized protein Dmel_CG9485, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163234.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD6, E1JGQ5

Conserved Domains (6) summary

cd11327
Location:146 → 638

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:25 → 1555

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:1081 → 1550

GDE_C; Amylo-alpha-1,6-glucosidase

pfam14699
Location:34 → 158

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:744 → 1014

hGDE_central; central domain of human glycogen debranching enzyme

cl10013
Location:1010 → 1084

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NM_166443.2 → NP_726061.1 uncharacterized protein Dmel_CG9485, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726061.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD6, Q7KVP4

Related

FBpp0071525

Conserved Domains (6) summary

cd11327
Location:125 → 617

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:25 → 1534

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:1060 → 1529

GDE_C; Amylo-alpha-1,6-glucosidase

pfam14699
Location:34 → 137

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:723 → 993

hGDE_central; central domain of human glycogen debranching enzyme

cl10013
Location:989 → 1063

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NM_001169764.2 → NP_001163235.1 uncharacterized protein Dmel_CG9485, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163235.1

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD6, Q7KVP4

Conserved Domains (6) summary

cd11327
Location:125 → 617

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:25 → 1534

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:1060 → 1529

GDE_C; Amylo-alpha-1,6-glucosidase

pfam14699
Location:34 → 137

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:723 → 993

hGDE_central; central domain of human glycogen debranching enzyme

cl10013
Location:989 → 1063

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NM_166444.2 → NP_726062.2 uncharacterized protein Dmel_CG9485, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726062.2

Status: REVIEWED

UniProtKB/TrEMBL

C7LAB1, Q9W2H8

Related

FBpp0071526

Conserved Domains (7) summary

cd11327
Location:212 → 704

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:112 → 1621

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:1147 → 1616

GDE_C; Amylo-alpha-1,6-glucosidase

pfam06870
Location:30 → 76

RNA_pol_I_A49; A49-like RNA polymerase I associated factor

pfam14699
Location:121 → 224

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:810 → 1080

hGDE_central; central domain of human glycogen debranching enzyme

cl10013
Location:1076 → 1150

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
NM_137733.3 → NP_611577.2 uncharacterized protein Dmel_CG9485, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611577.2

Status: REVIEWED

UniProtKB/TrEMBL

C7LAD6, Q86BS7

Related

FBpp0071527

Conserved Domains (6) summary

cd11327
Location:129 → 621

AmyAc_Glg_debranch_2; Alpha amylase catalytic domain found in glycogen debranching enzymes

TIGR01531
Location:29 → 1538

glyc_debranch; glycogen debranching enzymye

pfam06202
Location:1064 → 1533

GDE_C; Amylo-alpha-1,6-glucosidase

pfam14699
Location:38 → 141

hGDE_N; N-terminal domain from the human glycogen debranching enzyme

pfam14702
Location:727 → 997

hGDE_central; central domain of human glycogen debranching enzyme

cl10013
Location:993 → 1067

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...