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    ord orientation disruptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ordprovided by FlyBase
    Official Full Name
    orientation disruptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003009
    Locus tag
    Dmel_CG3134
    See related
    AllianceGenome:FB:FBgn0003009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3134; Dmel\CG3134; Ord; ORD
    Summary
    Involved in several processes, including maintenance of protein location in nucleus; male meiosis chromosome segregation; and meiotic sister chromatid cohesion. Located in chromosome; germ cell nucleus; and nuclear envelope. Is expressed in spermatocyte and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ord in Genome Data Viewer
    Location:
    59D4-59D4; 2-102 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23271257..23275536, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19158780..19163059, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene atlas

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orientation disruptor (ord): a recombination-defective and disjunction-defective meiotic mutant in Drosophila melanogaster. Mason JM. Genetics, 1976 Nov. PMID 826453, Free PMC Article
    2. A model system for increased meiotic nondisjunction in older oocytes. Jeffreys CA, et al. Curr Biol, 2003 Mar 18. PMID 12646133
    3. Human meiosis: model organisms address the maternal age effect. Hawley RS. Curr Biol, 2003 Apr 15. PMID 12699640
    4. Heterochromatin-mediated association of achiasmate homologs declines with age when cohesion is compromised. Subramanian VV, et al. Genetics, 2009 Apr. PMID 19204374, Free PMC Article
    5. Meiosis in Drosophila melanogaster, III. The effect of orientation disruptor (ord) on gonial mitotic and the meiotic divisions in males. Lin HP, et al. Genetics, 1982 Dec. PMID 6821250, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. If ORD activity is more severely disrupted, achiasmate chromosomes with the normal amount of pericentric heterochromatin exhibit increased nondisjunction when oocytes age.
      Title: Heterochromatin-mediated association of achiasmate homologs declines with age when cohesion is compromised.
    2. Results suggest that association of orientation disruptor (ORD) with meiotic chromosomes during mid to late G2 is required to maintain sister-chromatid cohesion during prophase condensation.
      Title: Meiotic cohesion requires accumulation of ORD on chromosomes before condensation.
    3. Results suggest that orientation disruptor (ord) activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, promoting homologue bias during meiotic recombination in Drosophila.
      Title: The cohesion protein ORD is required for homologue bias during meiotic recombination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    orientation disruptor
    Names
    CG3134-PA
    CG3134-PB
    ord-PA
    ord-PB
    orientation disrupter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23271257..23275536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166589.2 → NP_726303.1  orientation disruptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726303.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24434, Q9W1S8
      UniProtKB/TrEMBL
      D4G7E4
      Related
      FBpp0071956
      Conserved Domains (1) summary
      PRK07632
      Location:372 → 445
      PRK07632; ribonucleotide-diphosphate reductase subunit alpha; Validated

    2. NM_001299831.1 → NP_001286760.1  orientation disruptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286760.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24434, Q9W1S8
      UniProtKB/TrEMBL
      D4G7E4
      Conserved Domains (1) summary
      PRK07632
      Location:372 → 445
      PRK07632; ribonucleotide-diphosphate reductase subunit alpha; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4G7E4 D4G7E4
    Q24434.2 Q24434

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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