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    TBPH TAR DNA-binding protein-43 homolog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TBPHprovided by FlyBase
    Official Full Name
    TAR DNA-binding protein-43 homologprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025790
    Locus tag
    Dmel_CG10327
    See related
    AllianceGenome:FB:FBgn0025790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10327; Dmel\CG10327; dmTDP43; dtar; dTBPH; dTDP; dTDP-43; tbph; Tbph; TDP-43; TDP43; TDPH
    Summary
    Enables GU repeat RNA binding activity and single-stranded DNA binding activity. Involved in several processes, including adult walking behavior; regulation of synapse organization; and synapse organization. Located in H zone; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; embryonic/larval midgut primordium; ganglia; mesoderm; and somatic muscle cell. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; frontotemporal dementia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TBPH in Genome Data Viewer
    Location:
    60A4-60A5; 2-105 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23859067..23862593, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19746590..19750116, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene glass bottom boat Neighboring gene benign gonial cell neoplasm Neighboring gene Partner of Y14 and Mago Neighboring gene Ceramide phosphoethanolamine synthase Neighboring gene uncharacterized protein Neighboring gene Mitochondrial trifunctional protein beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy. Lo Piccolo L, et al. Neurotherapeutics, 2023 Sep. PMID 37493896, Free PMC Article
    2. Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye. Cragnaz L, et al. Neurobiol Dis, 2014 Nov. PMID 25088712
    3. TDP-43-mediated neuron loss in vivo requires RNA-binding activity. Voigt A, et al. PLoS One, 2010 Aug 18. PMID 20806063, Free PMC Article
    4. Standardized phytotherapic extracts rescue anomalous locomotion and electrophysiological responses of TDP-43 Drosophila melanogaster model of ALS. Maccioni R, et al. Sci Rep, 2018 Oct 30. PMID 30375462, Free PMC Article
    5. Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench. Franz CK, et al. J Neurophysiol, 2019 Sep 1. PMID 31116639, Free PMC Article

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization.
      Title: cAMP/PKA signaling regulates TDP-43 aggregation and mislocalization.
    2. Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.
      Title: Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.
    3. TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
      Title: TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1.
    4. TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance.
      Title: TDP-43 impairs sleep in Drosophila through Ataxin-2-dependent metabolic disturbance.
    5. Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.
      Title: Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.
    6. A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy.
      Title: A Novel Drosophila-based Drug Repurposing Platform Identified Fingolimod As a Potential Therapeutic for TDP-43 Proteinopathy.
    7. C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
      Title: C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
    8. TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
      Title: TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
    9. CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
      Title: CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.
    10. Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.
      Title: Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.
    Submit: New GeneRIF Correction See all GeneRIFs (48)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GU repeat RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of intracellular steroid hormone receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of intracellular steroid hormone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of intracellular steroid hormone receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule cytoskeleton organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal button organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in H zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TAR DNA-binding protein-43 homolog
    Names
    CG10327-PA
    CG10327-PB
    CG10327-PC
    CG10327-PD
    CG10327-PE
    CG10327-PF
    TAR DNA binding protein
    TBPH-PA
    TBPH-PB
    TBPH-PC
    TBPH-PD
    TBPH-PE
    TBPH-PF
    Tar DNA binding protein homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23859067..23862593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134318.3 → NP_599145.1  TAR DNA-binding protein-43 homolog, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97468, Q8SXP8, Q9W1I1
      Related
      FBpp0088568
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:192 → 261
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

    2. NM_058052.4 → NP_477400.1  TAR DNA-binding protein-43 homolog, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97468, Q8SXP8, Q9W1I1
      Related
      FBpp0088567
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:192 → 261
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

    3. NM_001169810.2 → NP_001163281.1  TAR DNA-binding protein-43 homolog, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163281.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97468, Q8SXP8, Q9W1I1
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:192 → 261
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

    4. NM_058051.4 → NP_477399.1  TAR DNA-binding protein-43 homolog, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97469, Q9W1I0
      Related
      FBpp0088569
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:192 → 261
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

    5. NM_166628.3 → NP_726373.1  TAR DNA-binding protein-43 homolog, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97468, Q8SXP8, Q9W1I1
      Related
      FBpp0088570
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:192 → 261
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins

    6. NM_001169809.2 → NP_001163280.1  TAR DNA-binding protein-43 homolog, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163280.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97468, Q8SXP8, Q9W1I1
      Conserved Domains (2) summary
      cd12321
      Location:108 → 184
      RRM1_TDP43; RNA recognition motif 1 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
      cd12322
      Location:192 → 261
      RRM2_TDP43; RNA recognition motif 2 in TAR DNA-binding protein 43 (TDP-43) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97468 O97468
    O97469 O97469
    Q8SXP8 Q8SXP8
    Q9W1I0 Q9W1I0

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