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    NLaz Neural Lazarillo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NLazprovided by FlyBase
    Official Full Name
    Neural Lazarilloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053126
    Locus tag
    Dmel_CG33126
    See related
    AllianceGenome:FB:FBgn0053126
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE67583; CG16933; CG33126; CT33980; Dmel\CG33126; DNLaz; nlaz; Nlaz
    Summary
    Predicted to enable pigment binding activity. Involved in several processes, including carbohydrate homeostasis; determination of adult lifespan; and triglyceride homeostasis. Located in extracellular space. Is expressed in several structures, including adult head; amnioserosa; ganglia; gut section; and larval CNS neuron. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See NLaz in Genome Data Viewer
    Location:
    22A1-22A1; 2-3 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1359837..1361821, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1359837..1361821, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44898 Neighboring gene antisense RNA:CR44897 Neighboring gene roundabout 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo. Pasco MY, et al. PLoS One, 2012. PMID 22567167, Free PMC Article
    2. Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. Ruiz M, et al. Exp Gerontol, 2011 Jul. PMID 21376794
    3. Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. Ruiz M, et al. Insect Biochem Mol Biol, 2012 Oct. PMID 22846641
    4. Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation. Ruiz M, et al. FEBS J, 2013 Aug. PMID 23777559
    5. Apolipoprotein D in Oxidative Stress and Inflammation. Fyfe-Desmarais G, et al. Antioxidants (Basel), 2023 Apr 28. PMID 37237893, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that NLazWT has stronger cell survival-promoting activity than NLazL130R under oxidative stress in a cell culture-based assay.
      Title: Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila.
    2. Data suggest that NLaz binds lyophilic ligands: retinoic acid, retinol, fatty acids, sphingomyelin, ergosterol, 7-tricosene. NLaz successfully delivers retinoic acid to immature neuronal cell line resulting in neurogenesis (i.e., neurite formation).
      Title: Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation.
    3. alters lifespan in both sexes
      Title: Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.
    4. NLaz is transcriptionally regulated by JNK signaling and is required for JNK-mediated stress.
      Title: Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pigment binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to reactive oxygen species IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neural lazarillo
    Names
    CG33126-PA
    CG33126-PB
    CG33126-PC
    NLaz-PA
    NLaz-PB
    NLaz-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1359837..1361821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298631.1 → NP_001285560.1  neural lazarillo, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXR1, Q9NAZ4, Q9VQ05
      Conserved Domains (1) summary
      cl21528
      Location:36 → 164
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_175946.2 → NP_787960.1  neural lazarillo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXR1, Q9NAZ4, Q9VQ05
      Related
      FBpp0077607
      Conserved Domains (1) summary
      cl21528
      Location:36 → 164
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    3. NM_001272938.2 → NP_001259867.1  neural lazarillo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBN2, Q9NAZ4
      Conserved Domains (1) summary
      cl21528
      Location:36 → 164
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBN2 M9PBN2
    Q8SXR1 Q8SXR1
    Q9NAZ4 Q9NAZ4

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