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    fred friend of echinoid [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fredprovided by FlyBase
    Official Full Name
    friend of echinoidprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051774
    Locus tag
    Dmel_CG31774
    See related
    AllianceGenome:FB:FBgn0051774
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12675; CG31774; CG3390; CG3393; CT11413; Dmel\CG31774; Fred
    Summary
    Predicted to enable cell adhesion molecule binding activity. Involved in adult chitin-based cuticle pattern formation; compound eye morphogenesis; and regulation of establishment of planar polarity. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in several structures, including adult head; epithelium; eye disc posterior to the morphogenetic furrow; imaginal disc; and presumptive embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fred in Genome Data Viewer
    Location:
    24C9-24D2; 2-11 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3902928..3991713, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3902928..3991713, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Centrosomal protein 97kDa Neighboring gene uncharacterized protein Neighboring gene cappuccino Neighboring gene Folylpolyglutamate synthase 2 Neighboring gene long non-coding RNA:CR45344 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee. Farooqui T, et al. J Neurosci, 2003 Jun 15. PMID 12832563, Free PMC Article
    2. Drosophila Echinoid is an antagonist of Egfr signalling, but is not a member of the L1-type family of cell adhesion molecules. Hortsch M. Development, 2003 Nov. PMID 14530293
    3. Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting. Chang LH, et al. Development, 2011 Sep. PMID 21795280
    4. The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway. Chandra S, et al. Dev Biol, 2003 Apr 15. PMID 12679104
    5. EGF receptor signaling: a prickly proposition. Firth LC, et al. Curr Biol, 2003 Sep 30. PMID 14521857

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. differential levels of Ed and Fred between stationary and rotating cells at the initiation of rotation create a permissive environment for cell movement, and uniform levels in these two populations later contribute to stopping the movement
      Title: The cell adhesion molecules Echinoid and Friend of Echinoid coordinate cell adhesion and cell signaling to regulate the fidelity of ommatidial rotation in the Drosophila eye.
    2. acts in close concert with the Notch signaling pathway
      Title: The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult chitin-based cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    friend of echinoid
    Names
    CG31774-PF
    CG31774-PG
    CG31774-PH
    fred-PF
    fred-PG
    fred-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3902928..3991713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258937.2 → NP_001245866.1  friend of echinoid, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4LU27, M9NCR3
      Conserved Domains (7) summary
      cd00096
      Location:635 → 713
      Ig; Immunoglobulin domain
      smart00408
      Location:330 → 385
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:141 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:720 → 838
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:232 → 313
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:416 → 501
      Ig_2; Immunoglobulin domain
      cl11960
      Location:147 → 228
      Ig; Immunoglobulin domain

    2. NM_164569.4 → NP_722954.3  friend of echinoid, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722954.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXX2, Q9VQW1
      Conserved Domains (7) summary
      cd00096
      Location:635 → 713
      Ig; Immunoglobulin domain
      smart00408
      Location:330 → 385
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:141 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:720 → 838
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:232 → 313
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:416 → 501
      Ig_2; Immunoglobulin domain
      cl11960
      Location:147 → 228
      Ig; Immunoglobulin domain

    3. NM_134968.4 → NP_608812.3  friend of echinoid, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608812.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GPK8
      Conserved Domains (7) summary
      cd00096
      Location:635 → 713
      Ig; Immunoglobulin domain
      smart00408
      Location:330 → 385
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:141 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:720 → 838
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:232 → 313
      I-set; Immunoglobulin I-set domain
      pfam13895
      Location:416 → 501
      Ig_2; Immunoglobulin domain
      cl11960
      Location:147 → 228
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GPK8 A0A023GPK8
    M9NCR3 M9NCR3
    Q8MZ57 Q8MZ57
    Q9VQW1 Q9VQW1

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