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    Trmt6 tRNA methyltransferase 6 non-catalytic subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt6provided by FlyBase
    Official Full Name
    tRNA methyltransferase 6 non-catalytic subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031832
    Locus tag
    Dmel_CG9596
    See related
    AllianceGenome:FB:FBgn0031832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9596; Dmel\CG9596; TRMT6
    Summary
    Predicted to be involved in tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; foregut primordium; hindgut proper primordium; and larval muscle system. Used to study candidiasis. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trmt6 in Genome Data Viewer
    Location:
    26E3-26E3; 2-21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6559426..6562289, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6559426..6562289, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport 52 Neighboring gene Cytochrome c oxidase subunit 5B Neighboring gene Cytochrome c oxidase subunit 5B-like Neighboring gene uncharacterized protein Neighboring gene Equilibrative nucleoside transporter 2 Neighboring gene Dipeptidyl peptidase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Shafik AM, et al. Hum Mol Genet, 2022 May 19. PMID 34897434, Free PMC Article
    2. Equilibrative nucleoside transporter 2 regulates associative learning and synaptic function in Drosophila. Knight D, et al. J Neurosci, 2010 Apr 7. PMID 20371825, Free PMC Article
    3. Analysis of insect nuclear small heat shock proteins and interacting proteins. Moutaoufik MT, et al. Cell Stress Chaperones, 2021 Jan. PMID 32888179, Free PMC Article
    4. A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection. Glittenberg MT, et al. Dis Model Mech, 2022 May 1. PMID 35142345, Free PMC Article
    5. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase 6 non-catalytic subunit
    Names
    CG9596-PB
    CG9596-PC
    CG9596-PD
    Trmt6-PB
    Trmt6-PC
    Trmt6-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6559426..6562289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298750.1 → NP_001285679.1  tRNA methyltransferase 6 non-catalytic subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285679.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS69
      Conserved Domains (1) summary
      pfam04189
      Location:9 → 309
      Gcd10p; Gcd10p family

    2. NM_135204.3 → NP_609048.2  tRNA methyltransferase 6 non-catalytic subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609048.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS69
      Conserved Domains (1) summary
      pfam04189
      Location:9 → 309
      Gcd10p; Gcd10p family

    3. NM_205916.2 → NP_995638.1  tRNA methyltransferase 6 non-catalytic subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS69
      Conserved Domains (1) summary
      pfam04189
      Location:9 → 309
      Gcd10p; Gcd10p family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS69 Q8MS69

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