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    Mco1 Multicopper oxidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34258, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mco1provided by FlyBase
    Official Full Name
    Multicopper oxidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032116
    Locus tag
    Dmel_CG3759
    See related
    AllianceGenome:FB:FBgn0032116
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3759; Dmel\CG3759; MCO1
    Summary
    Enables L-ascorbate oxidase activity and ferroxidase activity. Predicted to be involved in iron ion transport. Located in basal part of cell and cell surface. Is expressed in adult Malpighian tubule; adult head; adult midgut epithelium; embryonic/larval Malpighian tubule; and larval midgut epithelium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mco1 in Genome Data Viewer
    Location:
    30B2-30B3; 2-35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9416588..9426342)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9416588..9426342)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Shaw-like Neighboring gene Aldehyde dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fat body protein 2 Neighboring gene alpha1,3-fucosyltransferase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multicopper oxidase-1 orthologs from diverse insect species have ascorbate oxidase activity. Peng Z, et al. Insect Biochem Mol Biol, 2015 Apr. PMID 25701385, Free PMC Article
    2. Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. Lang M, et al. Proc Natl Acad Sci U S A, 2012 Aug 14. PMID 22847425, Free PMC Article
    3. Insect multicopper oxidases: diversity, properties, and physiological roles. Dittmer NT, et al. Insect Biochem Mol Biol, 2010 Mar. PMID 20219675
    4. Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase. Bettedi L, et al. J Exp Biol, 2011 Mar 15. PMID 21346125
    5. Molecular physiology of iron trafficking in Drosophila melanogaster. Wu S, et al. Curr Opin Insect Sci, 2022 Apr. PMID 35158107

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multicopper oxidase 1
    Names
    CG3759-PA
    CG3759-PB
    CG3759-PC
    Mco1-PA
    Mco1-PB
    Mco1-PC
    laccase-like
    multicopper oxidase-1
    NP_001188754.1
    NP_001188755.1
    NP_609287.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9416588..9426342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201825.2 → NP_001188754.1  multicopper oxidase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYT6, Q9VLC3
      Conserved Domains (5) summary
      smart00214
      Location:150 → 212
      VWC; von Willebrand factor (vWF) type C domain
      cd13858
      Location:293 → 397
      CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
      cd13884
      Location:415 → 626
      CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      cd13905
      Location:728 → 897
      CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      TIGR03388
      Location:293 → 905
      ascorbase; L-ascorbate oxidase, plant type

    2. NM_001201826.2 → NP_001188755.1  multicopper oxidase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYT6, Q9VLC3
      Conserved Domains (5) summary
      smart00214
      Location:150 → 212
      VWC; von Willebrand factor (vWF) type C domain
      cd13858
      Location:293 → 397
      CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
      cd13884
      Location:415 → 626
      CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      cd13905
      Location:728 → 897
      CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      TIGR03388
      Location:293 → 905
      ascorbase; L-ascorbate oxidase, plant type

    3. NM_135443.5 → NP_609287.3  multicopper oxidase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609287.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYT6, Q9VLC3
      Related
      FBpp0079407
      Conserved Domains (5) summary
      smart00214
      Location:150 → 212
      VWC; von Willebrand factor (vWF) type C domain
      cd13858
      Location:293 → 397
      CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
      cd13884
      Location:415 → 626
      CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      cd13905
      Location:728 → 897
      CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      TIGR03388
      Location:293 → 905
      ascorbase; L-ascorbate oxidase, plant type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYT6 Q8SYT6
    Q9VLC3 Q9VLC3

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