heix heixuedian [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: heixprovided by FlyBase
Official Full Name: heixuedianprovided by FlyBase
Primary source: FLYBASE:FBgn0028375
Locus tag: Dmel_CG5876
See related: AllianceGenome:FB:FBgn0028375
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 124/1; 2L1; BG:DS02740.7; CG5876; Dmel\CG5876; ipa-6d; l(2)35Fc; l(2)k12401
Summary: Predicted to enable prenyltransferase activity. Involved in several processes, including menaquinone biosynthetic process; negative regulation of hemocyte proliferation; and negative regulation of lamellocyte differentiation. Located in endoplasmic reticulum and mitochondrion. Is expressed in adult head; cortical zone of lymph gland primary lobe; embryonic/larval hemocyte; head mesoderm; and prohemocyte. Used to study lymphoma. Human ortholog(s) of this gene implicated in Schnyder corneal dystrophy. Orthologous to human UBIAD1 (UbiA prenyltransferase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35F1-35F1; 2-52 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16296051..16299858, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16296051..16299858, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggested that heix is a potential melanotic tumor suppressor gene and plays a pivotal role in both hemocytes proliferation and differentiation in Drosophila.
Title: Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during Drosophila hematopoiesis.
study identified UBIAD1/Heix as a modifier of pink1
Title: Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2137 (e-PCR)
- UniSTS:62298

Dm2136 (e-PCR)
- UniSTS:17899

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables prenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in menaquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in menaquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lamellocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heixuedian

Names: CG5876-PA; heix-PA; lethal(2)35Fc

NP_523581.1

EC 2.5.1.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16296051..16299858 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078857.4 → NP_523581.1 heixuedian [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523581.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V3R8

Related

FBpp0080409

Conserved Domains (1) summary

cd13962
Location:65 → 344

PT_UbiA_UBIAD1; 1,4-Dihydroxy-2-naphthoate octaprenyltransferase