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    Ae2 Anion exchanger 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39147, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ae2provided by FlyBase
    Official Full Name
    Anion exchanger 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036043
    Locus tag
    Dmel_CG8177
    See related
    AllianceGenome:FB:FBgn0036043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ae2; anon-EST:Posey259; BcDNA:RE59468; CG8177; DAE; Dmel\CG8177
    Summary
    Predicted to enable transmembrane transporter activity. Involved in intracellular pH reduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult brain; adult head; embryonic/larval midgut; ganglia; and larval midgut enterocyte. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; osteopetrosis; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)); SLC4A2 (solute carrier family 4 member 2); and SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ae2 in Genome Data Viewer
    Location:
    67C7-67C8; 3-31 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9763544..9786466)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9756644..9779566)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44348 Neighboring gene long non-coding RNA:CR45407 Neighboring gene uncharacterized protein Neighboring gene Z band alternatively spliced PDZ-motif protein 67 Neighboring gene Insulin-like peptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila anion exchanger 2 is required for proper ovary development and oogenesis. Benitez M, et al. Dev Biol, 2019 Aug 15. PMID 31071312, Free PMC Article
    2. The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton. Dubreuil RR, et al. J Negat Results Biomed, 2010 Jun 23. PMID 20573195, Free PMC Article
    3. Cloning and characterization of a Na+-driven anion exchanger (NDAE1). A new bicarbonate transporter. Romero MF, et al. J Biol Chem, 2000 Aug 11. PMID 10827195
    4. Increased intracellular pH is necessary for adult epithelial and embryonic stem cell differentiation. Ulmschneider B, et al. J Cell Biol, 2016 Nov 7. PMID 27821494, Free PMC Article
    5. Long-range targeted manipulation of the Drosophila genome by site-specific integration and recombinational resolution. Wesolowska N, et al. Genetics, 2013 Feb. PMID 23150601, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ae2 null flies have smaller ovaries, reduced fertility, and impaired follicle formation.
      Title: Drosophila anion exchanger 2 is required for proper ovary development and oogenesis.
    2. The well-characterized interaction between AE1 and the spectrin cytoskeleton in erythrocytes is not conserved in Drosophila.
      Title: The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anion exchanger 2
    Names
    Ae2-PA
    Ae2-PB
    Ae2-PC
    Ae2-PD
    Ae2-PE
    Ae2-PF
    Ae2-PG
    Ae2-PH
    Ae2-PI
    Ae2-PJ
    Ae2-PK
    Ae2-PL
    Ae2-PM
    CG8177-PA
    CG8177-PB
    CG8177-PC
    CG8177-PD
    CG8177-PE
    CG8177-PF
    CG8177-PG
    CG8177-PH
    CG8177-PI
    CG8177-PJ
    CG8177-PK
    CG8177-PL
    CG8177-PM
    drosophila anion exchanger

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9763544..9786466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274724.2 → NP_001261653.1  anion exchanger 2, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEQ4, Q6NL70
      Conserved Domains (3) summary
      TIGR00834
      Location:269 → 1209
      ae; anion exchange protein
      pfam00955
      Location:640 → 1141
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:296 → 560
      Band_3_cyto; Band 3 cytoplasmic domain

    2. NM_168371.3 → NP_729548.1  anion exchanger 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD6
      Related
      FBpp0076046
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1200
      ae; anion exchange protein
      pfam00955
      Location:631 → 1132
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 551
      Band_3_cyto; Band 3 cytoplasmic domain

    3. NM_206312.3 → NP_996034.1  anion exchanger 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q7KUD6
      Conserved Domains (3) summary
      TIGR00834
      Location:225 → 1165
      ae; anion exchange protein
      pfam00955
      Location:596 → 1097
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:252 → 516
      Band_3_cyto; Band 3 cytoplasmic domain

    4. NM_168369.2 → NP_729546.1  anion exchanger 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729546.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q9VT48
      Related
      FBpp0076048
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1267
      ae; anion exchange protein
      pfam00955
      Location:698 → 1199
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 618
      Band_3_cyto; Band 3 cytoplasmic domain

    5. NM_206314.3 → NP_996036.1  anion exchanger 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996036.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD6
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1200
      ae; anion exchange protein
      pfam00955
      Location:631 → 1132
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 551
      Band_3_cyto; Band 3 cytoplasmic domain

    6. NM_206311.2 → NP_996033.1  anion exchanger 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q7KUD7
      Conserved Domains (3) summary
      TIGR00834
      Location:225 → 1232
      ae; anion exchange protein
      pfam00955
      Location:663 → 1164
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:252 → 583
      Band_3_cyto; Band 3 cytoplasmic domain

    7. NM_206313.2 → NP_996035.1  anion exchanger 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996035.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD6
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1200
      ae; anion exchange protein
      pfam00955
      Location:631 → 1132
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 551
      Band_3_cyto; Band 3 cytoplasmic domain

    8. NM_168372.2 → NP_729549.1  anion exchanger 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD6
      Related
      FBpp0076047
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1200
      ae; anion exchange protein
      pfam00955
      Location:631 → 1132
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 551
      Band_3_cyto; Band 3 cytoplasmic domain

    9. NM_168370.3 → NP_729547.1  anion exchanger 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD6
      Related
      FBpp0076049
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1200
      ae; anion exchange protein
      pfam00955
      Location:631 → 1132
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 551
      Band_3_cyto; Band 3 cytoplasmic domain

    10. NM_140100.2 → NP_648357.1  anion exchanger 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q9VT48
      Related
      FBpp0076050
      Conserved Domains (3) summary
      TIGR00834
      Location:260 → 1267
      ae; anion exchange protein
      pfam00955
      Location:698 → 1199
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:287 → 618
      Band_3_cyto; Band 3 cytoplasmic domain

    11. NM_168373.3 → NP_729550.1  anion exchanger 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729550.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD5
      Related
      FBpp0076052
      Conserved Domains (3) summary
      TIGR00834
      Location:220 → 1227
      ae; anion exchange protein
      pfam00955
      Location:658 → 1159
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:247 → 578
      Band_3_cyto; Band 3 cytoplasmic domain

    12. NM_168374.2 → NP_729551.1  anion exchanger 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL70, Q8IQD4
      Related
      FBpp0076051
      Conserved Domains (3) summary
      TIGR00834
      Location:220 → 1160
      ae; anion exchange protein
      pfam00955
      Location:591 → 1092
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:247 → 511
      Band_3_cyto; Band 3 cytoplasmic domain

    13. NM_001169931.2 → NP_001163402.1  anion exchanger 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163402.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PD2
      Conserved Domains (1) summary
      pfam07565
      Location:247 → 346
      Band_3_cyto; Band 3 cytoplasmic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEQ4 M9PEQ4
    Q7KUD6 Q7KUD6
    Q7KUD7 Q7KUD7
    Q86PD2 Q86PD2
    Q8IQD4 Q8IQD4
    Q8IQD5 Q8IQD5
    Q8IQD6 Q8IQD6
    Q8MRK3 Q8MRK3
    Q95SW2 Q95SW2
    Q9VT48 Q9VT48

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