U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    ND-MLRQ NADH dehydrogenase (ubiquinone) MLRQ subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317928, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ND-MLRQprovided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) MLRQ subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052230
    Locus tag
    Dmel_CG32230
    See related
    AllianceGenome:FB:FBgn0052230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE56733; BEST:GH04411; CG32230; Dmel\CG32230; NDUFA4; NUML; Q8SYJ2
    Summary
    Predicted to be part of respiratory chain complex IV. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 21. Orthologous to human NDUFA4 (NDUFA4 mitochondrial complex associated) and NDUFA4L2 (NDUFA4 mitochondrial complex associated like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ND-MLRQ in Genome Data Viewer
    Location:
    80F2-80F2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23339326..23345936)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23332426..23339036)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha4 Neighboring gene long non-coding RNA:CR46475 Neighboring gene alpha Catenin Neighboring gene mir-4942 stem loop Neighboring gene Argonaute 3 Neighboring gene long non-coding RNA:CR45174

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative proteomics analysis of dietary restriction in Drosophila. Gao Y, et al. PLoS One, 2020. PMID 33064752, Free PMC Article
    2. α-Catenin stabilises Cadherin-Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction. Jurado J, et al. J Cell Sci, 2016 Dec 15. PMID 27831494
    3. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
    4. Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq. Aspden JL, et al. Elife, 2014 Aug 21. PMID 25144939, Free PMC Article
    5. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 23339885-23340321 mobile_element_type = transposon:INE-1{}4071
    • Loc: 23344099-23344783 mobile_element_type = transposon:1360{}1160

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH dehydrogenase (ubiquinone) MLRQ subunit
    Names
    CG32230-PA
    CG32230-PB
    CG32230-PC
    NADH ubiquinone oxidoreductase MLRQ
    NADH-ubiquinone oxidoreductase MLRQ subunit
    NADH:ubiquinone oxidoreductase MLRQ subunit
    ND-MLRQ-PA
    ND-MLRQ-PB
    ND-MLRQ-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      23339326..23345936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275306.2 → NP_001262235.1  NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262235.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYJ2
      Conserved Domains (1) summary
      pfam06522
      Location:11 → 76
      B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

    2. NM_168988.3 → NP_730777.1  NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYJ2
      Related
      FBpp0070039
      Conserved Domains (1) summary
      pfam06522
      Location:11 → 76
      B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit

    3. NM_168989.3 → NP_730778.1  NADH dehydrogenase (ubiquinone) MLRQ subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYJ2
      Related
      FBpp0070040
      Conserved Domains (1) summary
      pfam06522
      Location:11 → 76
      B12D; NADH-ubiquinone reductase complex 1 MLRQ subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYJ2 Q8SYJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous