Ccnf cyclin F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnfprovided by MGI
Official Full Name: cyclin Fprovided by MGI
Primary source: MGI:MGI:102551
See related: Ensembl:ENSMUSG00000072082 AllianceGenome:MGI:102551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CycF; Fbxo1
Summary: Predicted to enable anaphase-promoting complex binding activity and cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within negative regulation of centrosome duplication; placenta development; and re-entry into mitotic cell cycle. Predicted to be located in cell junction; centriole; and centrosome. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in liver lobe; midbrain ventricular layer; and telencephalon. Orthologous to human CCNF (cyclin F). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14.5 (RPKM 29.9), thymus adult (RPKM 27.8) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.32 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24441518..24470333, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24223230..24251409, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism.
Title: Injury-induced Foxm1 expression in the mouse kidney drives epithelial proliferation by a cyclin F-dependent mechanism.
Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity
Title: Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.
SCF(Cyclin F)-mediated degradation of CP110 is required for the fidelity of mitosis and genome integrity
Title: SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
CycF(-/-) animals, with a myriad of developmental anomalies due in large part to failures in yolk sac and chorioallantoic placentation, die around embryonic day 10.5.
Title: Cyclin F disruption compromises placental development and affects normal cell cycle execution.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225311

RH118367 (e-PCR)
- UniSTS:160990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables anaphase-promoting complex binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within re-entry into mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-F

Names: G2/mitotic-specific cyclin-F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409800.1 → NP_001396729.1 cyclin-F isoform 1

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409801.1 → NP_001396730.1 cyclin-F isoform 2

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409803.1 → NP_001396732.1 cyclin-F isoform 5

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409804.1 → NP_001396733.1 cyclin-F isoform 6

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409805.1 → NP_001396734.1 cyclin-F isoform 7

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409806.1 → NP_001396735.1 cyclin-F isoform 8

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409807.1 → NP_001396736.1 cyclin-F isoform 9

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409808.1 → NP_001396737.1 cyclin-F isoform 9

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409809.1 → NP_001396738.1 cyclin-F isoform 3

Status: VALIDATED

Source sequence(s)

AC117577
NM_001409832.1 → NP_001396761.1 cyclin-F isoform 10

Status: VALIDATED

Source sequence(s)

AC117577
NM_007634.5 → NP_031660.3 cyclin-F isoform 4

See identical proteins and their annotated locations for NP_031660.3

Status: VALIDATED

Source sequence(s)

AC117577

Consensus CDS

CCDS37484.1

UniProtKB/Swiss-Prot

P51944, Q3TF73, Q60797, Q60799, Q8BSX9, Q8C4D9, Q8CI26

Related

ENSMUSP00000111048.4, ENSMUST00000115390.5

Conserved Domains (3) summary

smart00256
Location:35 → 73

FBOX; A Receptor for Ubiquitination Targets

pfam00134
Location:281 → 406

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:425 → 531

Cyclin_C; Cyclin, C-terminal domain