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    Rpl6 ribosomal protein L6 [ Mus musculus (house mouse) ]

    Gene ID: 19988, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpl6provided by MGI
    Official Full Name
    ribosomal protein L6provided by MGI
    Primary source
    MGI:MGI:108057
    See related
    Ensembl:ENSMUSG00000029614 AllianceGenome:MGI:108057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Taxreb107
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Is expressed in several structures, including genitourinary system; intestine; liver; lung; and spleen. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 369.7), CNS E11.5 (RPKM 369.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl6 in Genome Data Viewer
    Location:
    5 F; 5 61.72 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121342564..121347304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121204501..121209241)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32185 Neighboring gene rabphilin 3A Neighboring gene STARR-positive B cell enhancer ABC_E3611 Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene STARR-positive B cell enhancer ABC_E4783 Neighboring gene STARR-positive B cell enhancer ABC_E6372 Neighboring gene STARR-seq mESC enhancer starr_14255 Neighboring gene STARR-positive B cell enhancer ABC_E4784 Neighboring gene predicted gene, 26205 Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr5:121780251-121780552 Neighboring gene predicted gene, 24671 Neighboring gene predicted gene, 42020 Neighboring gene TRAF type zinc finger domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse homologue of the HTLV-I tax responsive element binding protein TAXREB107 is a highly conserved gene which may regulate some basal cellular functions. Nacken W, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7537974
    2. Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells. Wittlin S, et al. Biochim Biophys Acta, 2003 Oct 21. PMID 14572897
    3. Isolation and characterization of chicken TaxREB107, a putative DNA binding protein abundantly expressed in muscle. Thomson SR, et al. Gene, 2001 Oct 31. PMID 11707324
    4. Identification and verification of novel rodent postsynaptic density proteins. Jordan BA, et al. Mol Cell Proteomics, 2004 Sep. PMID 15169875
    5. Cloning of mouse genomic ribosomal protein L6 gene and analysis of its promoter. Wang J, et al. Biochim Biophys Acta, 2002 Jun 7. PMID 12031506

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taxreb107 has a role as a lactogenic hormone-responsive gene during differentiation of the mammary gland.
      Title: Identification of Taxreb107 as a lactogenic hormone responsive gene in mammary epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117949

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5.8S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL6
    Names
    60S ribosomal protein L6
    TAX-responsive enhancer element-binding protein 107

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421310.1 → NP_001408239.1  large ribosomal subunit protein eL6

      Status: VALIDATED

      Source sequence(s)
      AC110037
      UniProtKB/Swiss-Prot
      P47911, Q6P5I2, Q925C3
      UniProtKB/TrEMBL
      Q3UCH0, Q3UFI4

    2. NM_011290.5 → NP_035420.2  large ribosomal subunit protein eL6

      See identical proteins and their annotated locations for NP_035420.2

      Status: VALIDATED

      Source sequence(s)
      AK151022, AK153208, CJ316043
      Consensus CDS
      CCDS19632.1
      UniProtKB/Swiss-Prot
      P47911, Q6P5I2, Q925C3
      UniProtKB/TrEMBL
      Q3UCH0, Q3UFI4
      Related
      ENSMUSP00000031617.10, ENSMUST00000031617.13
      Conserved Domains (2) summary
      cd13156
      Location:144 → 296
      KOW_RPL6; KOW motif of Ribosomal Protein L6
      pfam03868
      Location:50 → 103
      Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121342564..121347304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47911.3 GenPept UniProtKB/Swiss-Prot:P47911

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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