Mapk14 mitogen-activated protein kinase 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk14provided by MGI
Official Full Name: mitogen-activated protein kinase 14provided by MGI
Primary source: MGI:MGI:1346865
See related: Ensembl:ENSMUSG00000053436 AllianceGenome:MGI:1346865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha
Summary: Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in mitochondrion; nucleus; and spindle pole. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; head mesenchyme; and telencephalon. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 35.2), thymus adult (RPKM 34.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 14.85 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (28910316..28967379)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28691342..28748405)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis.
Title: Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis.
Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.
Title: Lysosome-related organelle integrity suppresses TIR-1 aggregation to restrain toxic propagation of p38 innate immunity.
Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.
Title: Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.
P38alpha MAPK Coordinates Mitochondrial Adaptation to Caloric Surplus in Skeletal Muscle.
Title: P38α MAPK Coordinates Mitochondrial Adaptation to Caloric Surplus in Skeletal Muscle.
The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.
Title: The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.
Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis.
Title: Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis.
GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14.
Title: GSNOR negatively regulates the NLRP3 inflammasome via S-nitrosation of MAPK14.
Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway.
Title: Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway.
CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.
Title: CLCA1 exacerbates lung inflammation via p38 MAPK pathway in acute respiratory distress syndrome.
Shank3 deficiency elicits autistic-like behaviors by activating p38alpha in hypothalamic AgRP neurons.
Title: Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons.

Submit: New GeneRIF Correction See all GeneRIFs (955)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (17) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

10.MMHAP76FRD7.seq (e-PCR)
- UniSTS:123048

U10871 (e-PCR)
- UniSTS:125664

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NFAT protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mitogen-activated protein kinase p38 binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase p38 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
acts_upstream_of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cartilage condensation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to lipoteichoic acid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cyclase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic membrane adhesion	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to muscle stretch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in stress-induced premature senescence	IEA Inferred from Electronic Annotation more info
involved_in stress-induced premature senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase 14

Names: MAP kinase 14; MAP kinase p38 alpha; MAPK 14; mitogen-activated protein kinase p38 alpha; p38 MAP kinase alpha; p38 MAPK

NP_001161980.1

EC 2.7.11.24

NP_001161985.1

EC 2.7.11.24

NP_001161986.1

EC 2.7.11.24

NP_001344653.1

EC 2.7.11.24

NP_036081.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168508.1 → NP_001161980.1 mitogen-activated protein kinase 14 isoform 2

See identical proteins and their annotated locations for NP_001161980.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1. This results in an isoform (2) of the same size, but with a different 27 aa protein segment compared to isoform 1.

Source sequence(s)

AC170998, AI132714, AK133684, CX568915, D83073

Consensus CDS

CCDS50048.1

UniProtKB/TrEMBL

Q5U421

Related

ENSMUSP00000004990.7, ENSMUST00000004990.14

Conserved Domains (1) summary

cd07877
Location:6 → 350

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
NM_001168513.1 → NP_001161985.1 mitogen-activated protein kinase 14 isoform 3

See identical proteins and their annotated locations for NP_001161985.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3-5 encode the same isoform (3).

Source sequence(s)

AI132714, AK133684, AK151348

Consensus CDS

CCDS50049.1

UniProtKB/Swiss-Prot

P47811

Related

ENSMUSP00000110400.2, ENSMUST00000114752.3

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain
NM_001168514.1 → NP_001161986.1 mitogen-activated protein kinase 14 isoform 3

See identical proteins and their annotated locations for NP_001161986.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an additional exon at the 5' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3-5 encode the same isoform (3).

Source sequence(s)

AC170998, AI132714, AK133684

Consensus CDS

CCDS50049.1

UniProtKB/Swiss-Prot

P47811

Related

ENSMUSP00000110402.2, ENSMUST00000114754.8

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain
NM_001357724.1 → NP_001344653.1 mitogen-activated protein kinase 14 isoform 3

Status: VALIDATED

Source sequence(s)

AC170998, W66694

Conserved Domains (1) summary

cl21453
Location:1 → 273

PKc_like; Protein Kinases, catalytic domain
NM_011951.3 → NP_036081.1 mitogen-activated protein kinase 14 isoform 1

See identical proteins and their annotated locations for NP_036081.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC170998, AI132714, AK133684

Consensus CDS

CCDS28583.1

UniProtKB/Swiss-Prot

B2KF37, B2KF38, O08666, P47811, Q3U6R5, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80

Related

ENSMUSP00000061958.9, ENSMUST00000062694.16

Conserved Domains (1) summary

cd07877
Location:6 → 350

STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)