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    Mcm5 minichromosome maintenance complex component 5 [ Mus musculus (house mouse) ]

    Gene ID: 17218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcm5provided by MGI
    Official Full Name
    minichromosome maintenance complex component 5provided by MGI
    Primary source
    MGI:MGI:103197
    See related
    Ensembl:ENSMUSG00000005410 AllianceGenome:MGI:103197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdc46; Mcmd5; P1-CDC46
    Summary
    The protein encoded by this gene is a member of the oligameric minichromosome maintenance protein complex. During DNA replication, the complex loads onto chromatin in early G1 and is converted into an active replicative helicase during S phase. It functions to limit DNA synthesis to once per cell cycle. During embryogenesis, the encoded protein is negatively regulated through expression of paired box protein Pax 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Broad expression in liver E14.5 (RPKM 77.8), liver E14 (RPKM 74.7) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mcm5 in Genome Data Viewer
    Location:
    8 C1; 8 35.59 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (75836096..75855067)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (75109468..75128439)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21925 Neighboring gene STARR-seq mESC enhancer starr_21926 Neighboring gene STARR-positive B cell enhancer ABC_E8248 Neighboring gene dpy-30 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E244 Neighboring gene heme oxygenase 1 Neighboring gene STARR-seq mESC enhancer starr_21928 Neighboring gene RASD family, member 2 Neighboring gene STARR-seq mESC enhancer starr_21930 Neighboring gene STARR-seq mESC enhancer starr_21931 Neighboring gene predicted gene 9644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reduced expression of pax-3 is associated with overexpression of cdc46 in the mouse embryo. Hill AL, et al. Dev Genes Evol, 1998 May. PMID 9601985
    2. The structure and function of MCM from archaeal M. Thermoautotrophicum. Fletcher RJ, et al. Nat Struct Biol, 2003 Mar. PMID 12548282
    3. Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5. Su Z, et al. J Dermatol Sci, 2017 Mar. PMID 27955842
    4. Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Kimura H, et al. Nucleic Acids Res, 1995 Jun 25. PMID 7610039, Free PMC Article
    5. Comparative genomics RNAi screen identifies Eftud2 as a novel regulator of innate immunity. De Arras L, et al. Genetics, 2014 Jun. PMID 24361939, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SOX10 directly activates MCM5 transcription by binding to conserved SOX10 consensus DNA sequences in the MCM5 promoter.
      Title: Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA replication origin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA unwinding involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in premeiotic DNA replication NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CMG complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MCM complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MCM complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication licensing factor MCM5
    Names
    CDC46 homolog
    mini chromosome maintenance deficient 5
    minichromosome maintenance deficient 5, cell division cycle 46
    NP_001289469.1
    NP_032592.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302540.1 → NP_001289469.1  DNA replication licensing factor MCM5

      See identical proteins and their annotated locations for NP_001289469.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC084823, AK051795, BY576039, CJ075220
      Consensus CDS
      CCDS22424.1
      UniProtKB/Swiss-Prot
      P49718, Q52KC3
      UniProtKB/TrEMBL
      Q8BQ03
      Related
      ENSMUSP00000148648.2, ENSMUST00000212426.2
      Conserved Domains (3) summary
      smart00350
      Location:133 → 649
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:35 → 130
      MCM_N; MCM N-terminal domain
      NF033441
      Location:618 → 730
      BREX_BrxC; BREX system P-loop protein BrxC

    2. NM_008566.3 → NP_032592.2  DNA replication licensing factor MCM5

      See identical proteins and their annotated locations for NP_032592.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC084823, AK033196, CJ075220
      Consensus CDS
      CCDS22424.1
      UniProtKB/Swiss-Prot
      P49718, Q52KC3
      UniProtKB/TrEMBL
      Q8BQ03
      Related
      ENSMUSP00000126135.2, ENSMUST00000164309.3
      Conserved Domains (3) summary
      smart00350
      Location:133 → 649
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:35 → 130
      MCM_N; MCM N-terminal domain
      NF033441
      Location:618 → 730
      BREX_BrxC; BREX system P-loop protein BrxC

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      75836096..75855067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778410.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49718.2 GenPept UniProtKB/Swiss-Prot:P49718

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