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    DERPC DERPC proline and glycine rich nuclear protein [ Homo sapiens (human) ]

    Gene ID: 113455421, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DERPCprovided by HGNC
    Official Full Name
    DERPC proline and glycine rich nuclear proteinprovided by HGNC
    Primary source
    HGNC:HGNC:54084
    See related
    Ensembl:ENSG00000286140 AllianceGenome:HGNC:54084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    mouse all
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    Genomic context

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    See DERPC in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (69118010..69132588, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74914320..74928895, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69151913..69166491, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transport and golgi organization 6 homolog Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like Neighboring gene ribosomal protein S2 pseudogene 45 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69096798-69097616 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69105561-69106280 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:69106281-69106998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69106999-69107717 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69107718-69108435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69111819-69112338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69122977-69123854 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69131715-69132540 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:69133965-69134466 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:69139221-69139769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:69143266-69144235 Neighboring gene hyaluronan synthase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7653 Neighboring gene chromosome transmission fidelity factor 8 Neighboring gene Sharpr-MPRA regulatory region 12307 Neighboring gene UTP4 small subunit processome component Neighboring gene RNA, U6 small nuclear 22, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors. Sun M, et al. Mol Med, 2002 Oct. PMID 12477976, Free PMC Article
    2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. Zhou H, et al. J Proteome Res, 2013 Jan 4. PMID 23186163
    3. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast. Green AR, et al. Breast Cancer Res Treat, 2009 Jan. PMID 18213475
    4. Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and Disease. Bigaud E, et al. Mol Cell Proteomics, 2016 May. PMID 26819315, Free PMC Article
    5. A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. Shiomi Y, et al. J Biol Chem, 2007 Jul 20. PMID 17545166

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. decreased expression of DERPC may be implicated in tumorigenesis of prostate and renal tumors
      Title: A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Homology

    Clone Names

    • FLJ20400, DKFZp434K0218

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    decreased expression in renal and prostate cancer protein
    Names
    Protein DERPC
    chromosome transmission fidelity protein 8 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002847.4 → NP_001002847.1  decreased expression in renal and prostate cancer protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009027
      Consensus CDS
      CCDS92188.1
      UniProtKB/Swiss-Prot
      P0CG12
      UniProtKB/TrEMBL
      L0R4W3
      Related
      ENSP00000427718.2, ENST00000519520.7
      Conserved Domains (1) summary
      PHA03247
      Location:69 → 512
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001040144.3 → NP_001035234.2  decreased expression in renal and prostate cancer protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009027
      Consensus CDS
      CCDS92188.1
      UniProtKB/Swiss-Prot
      P0CG12
      UniProtKB/TrEMBL
      L0R4W3
      Conserved Domains (1) summary
      PHA03247
      Location:69 → 512
      PHA03247; large tegument protein UL36; Provisional

    3. NM_001366602.2 → NP_001353531.1  decreased expression in renal and prostate cancer protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009027

    4. NM_001366603.2 → NP_001353532.1  decreased expression in renal and prostate cancer protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009027
      Consensus CDS
      CCDS92188.1
      UniProtKB/Swiss-Prot
      P0CG12
      UniProtKB/TrEMBL
      L0R4W3
      Conserved Domains (1) summary
      PHA03247
      Location:69 → 512
      PHA03247; large tegument protein UL36; Provisional

    5. NM_001366604.2 → NP_001353533.1  decreased expression in renal and prostate cancer protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009027
      Consensus CDS
      CCDS92188.1
      UniProtKB/Swiss-Prot
      P0CG12
      UniProtKB/TrEMBL
      L0R4W3
      Related
      ENSP00000305687.6, ENST00000306585.9
      Conserved Domains (1) summary
      PHA03247
      Location:69 → 512
      PHA03247; large tegument protein UL36; Provisional

    6. NM_001366605.2 → NP_001353534.1  decreased expression in renal and prostate cancer protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009027

    7. NM_001366606.2 → NP_001353535.1  decreased expression in renal and prostate cancer protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009027

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      69118010..69132588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      74914320..74928895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CG12.1 GenPept UniProtKB/Swiss-Prot:P0CG12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials