Rhoj ras homolog family member J [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhojprovided by MGI
Official Full Name: ras homolog family member Jprovided by MGI
Primary source: MGI:MGI:1931551
See related: Ensembl:ENSMUSG00000046768 AllianceGenome:MGI:1931551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TCL; Arhj; TC10L; 1110005O19Rik
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin cytoskeleton organization. Acts upstream of or within Rho protein signal transduction; regulation of cell shape; and retina vasculature morphogenesis in camera-type eye. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; retina; and vertebral axis musculature. Orthologous to human RHOJ (ras homolog family member J). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 41.1), lung adult (RPKM 33.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 32.63 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (75355087..75448229)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (75308313..75401455)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Towards Understanding the Development of Breast Cancer: The Role of RhoJ in the Obesity Microenvironment.
Title: Towards Understanding the Development of Breast Cancer: The Role of RhoJ in the Obesity Microenvironment.
RHOJ controls EMT-associated resistance to chemotherapy.
Title: RHOJ controls EMT-associated resistance to chemotherapy.
RhoJ Regulates alpha5beta1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
Title: RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells.
Title: RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells.
ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis.
Title: ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis.
RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility.
Title: RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.
These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.
Title: Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.
RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.
Title: RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.
The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling mitotic clonal expansion and this regulatory effect is closely linked to C/EBPbeta and C/EBPdelta expression.
Title: TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion.
cloning and functional characterization of related isoforms
Title: Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Cdc42 protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoJ

Names: TC10-like Rho GTPase; ras homolog gene family, member J; tc10-like GTP-binding protein TCL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023275.2 → NP_075764.1 rho-related GTP-binding protein RhoJ

See identical proteins and their annotated locations for NP_075764.1

Status: VALIDATED

Source sequence(s)

AK003482, BY004626

Consensus CDS

CCDS25981.1

UniProtKB/Swiss-Prot

Q3TX76, Q920E4, Q9CQA7, Q9ER71

UniProtKB/TrEMBL

Q3TZU6

Related

ENSMUSP00000059498.6, ENSMUST00000055390.6

Conserved Domains (2) summary

smart00174
Location:24 → 197

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cl21455
Location:22 → 195

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases