Pdcd4 programmed cell death 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdcd4provided by MGI
Official Full Name: programmed cell death 4provided by MGI
Primary source: MGI:MGI:107490
See related: Ensembl:ENSMUSG00000024975 AllianceGenome:MGI:107490
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ma3; Tis; D19Ucla1
Summary: Predicted to enable RNA binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of cytokine production involved in inflammatory response; and positive regulation of inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; early conceptus; epithelium; oocyte; and thymus primordium. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 26.5), placenta adult (RPKM 14.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 48.73 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (53880662..53926024)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (53892231..53937592)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Title: Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression.
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARgamma/IL-10 signaling.
Title: Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling.
PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency.
Title: PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency.
MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4.
Title: MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4.
[PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].
Title: [PDCD4 knockdown ameliorates lipopolysaccharide-induced endothelial cell damage by improving mitochondrial dynamics].
CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
Title: CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury.
Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders.
Title: Programmed cell death 4 governs NLRP3-mediated pyroptosis in septic lung disorders.
miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4.
Title: miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4.
PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-kappaB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
Title: PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation.
Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.
Title: Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93337 (e-PCR)
- UniSTS:83971

AU017267 (e-PCR)
- UniSTS:209480

D19Mit36 (e-PCR), detects polymorphism
- UniSTS:128377

RH133731 (e-PCR)
- UniSTS:217014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of myofibroblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of myofibroblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to alkaloid	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: programmed cell death protein 4

Names: protein MA-3; topoisomerase-inhibitor suppressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168491.1 → NP_001161963.1 programmed cell death protein 4

See identical proteins and their annotated locations for NP_001161963.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC117612

Consensus CDS

CCDS29903.1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Related

ENSMUSP00000025931.7, ENSMUST00000025931.14

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
NM_001168492.1 → NP_001161964.1 programmed cell death protein 4

See identical proteins and their annotated locations for NP_001161964.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC117612, BC055739

Consensus CDS

CCDS29903.1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Related

ENSMUSP00000133135.2, ENSMUST00000165617.3

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
NM_011050.4 → NP_035180.2 programmed cell death protein 4

See identical proteins and their annotated locations for NP_035180.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC117612, AK134366

Consensus CDS

CCDS29903.1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Related

ENSMUSP00000073975.6, ENSMUST00000074371.13

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

53880662..53926024

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250768.2 → XP_030106628.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_036161459.1 → XP_036017352.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_006526762.5 → XP_006526825.1 programmed cell death protein 4 isoform X1

See identical proteins and their annotated locations for XP_006526825.1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_036161461.1 → XP_036017354.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_030250769.1 → XP_030106629.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
XM_036161460.1 → XP_036017353.1 programmed cell death protein 4 isoform X1

UniProtKB/Swiss-Prot

P97296, Q3T9A9, Q61823

Conserved Domains (1) summary

smart00544
Location:327 → 440

MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins