Snx2 sorting nexin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx2provided by MGI
Official Full Name: sorting nexin 2provided by MGI
Primary source: MGI:MGI:1915054
See related: Ensembl:ENSMUSG00000034484 AllianceGenome:MGI:1915054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610030A03Rik
Summary: Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in early endosome to Golgi transport and lamellipodium morphogenesis. Located in membrane. Is expressed in embryo; neocortex; small intestine; and yolk sac. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 55.9), bladder adult (RPKM 30.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 D1; 18 28.99 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (53309362..53353938)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (53176292..53220866)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BLOS1 interacts with sorting nexin 2 and the ESCRT-I component TSG101 to mediate the sorting of EGFR into endosomal compartments
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.
Data show that mice lacking sorting nexin 1 or sorting nexin 2 are viable and fertile, whereas embryos deficient in both proteins arrest at midgestation.
Title: Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.
Data describe a functional interaction between Hbeta58, sorting nexin 1 (SNX1), and SNX2 and strongly suggest that SNX2 plays a more critical role than SNX1 in retromer activity during embryonic development.
Title: Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC129968P1 (e-PCR)
- UniSTS:270605

Snx2 (e-PCR), detects polymorphism
- UniSTS:478960

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables leptin receptor binding	IEA Inferred from Electronic Annotation more info
enables leptin receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transferrin receptor binding	IEA Inferred from Electronic Annotation more info
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in early endosome to Golgi transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info
part_of retromer, tubulation complex	IEA Inferred from Electronic Annotation more info
part_of retromer, tubulation complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357463.1 → NP_001344392.1 sorting nexin-2 isoform 2

Status: VALIDATED

Source sequence(s)

AC127421, AC148020

UniProtKB/TrEMBL

Q3U5L3, Q91VZ1

Conserved Domains (3) summary

cd07282
Location:142 → 265

PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2

pfam03700
Location:49 → 112

Sorting_nexin; Sorting nexin, N-terminal domain

cl12013
Location:283 → 520

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_026386.2 → NP_080662.1 sorting nexin-2 isoform 1

See identical proteins and their annotated locations for NP_080662.1

Status: VALIDATED

Source sequence(s)

AC127421, AC148020, AK002692, AK145840

Consensus CDS

CCDS37821.1

UniProtKB/Swiss-Prot

Q3UKW3, Q9CQV0, Q9CWK8

UniProtKB/TrEMBL

Q3U5L3, Q91VZ1

Related

ENSMUSP00000039243.5, ENSMUST00000037850.7

Conserved Domains (4) summary

cd07282
Location:142 → 265

PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2

COG5391
Location:51 → 509

COG5391; Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]

pfam03700
Location:49 → 112

Sorting_nexin; Sorting nexin, N-terminal domain

cl12013
Location:283 → 516

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

53309362..53353938

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161259.1 → XP_036017152.1 sorting nexin-2 isoform X3

Conserved Domains (2) summary

cd07282
Location:20 → 143

PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2

cl12013
Location:161 → 398

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036161260.1 → XP_036017153.1 sorting nexin-2 isoform X4

Conserved Domains (2) summary

cd07282
Location:20 → 143

PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2

cl12013
Location:161 → 394

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030250577.2 → XP_030106437.1 sorting nexin-2 isoform X1

UniProtKB/TrEMBL

Q3U5L3, Q91VZ1

Conserved Domains (3) summary

cd07282
Location:90 → 213

PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2

pfam03700
Location:24 → 82

Sorting_nexin; Sorting nexin, N-terminal domain

cl12013
Location:231 → 468

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_036161258.1 → XP_036017151.1 sorting nexin-2 isoform X2

UniProtKB/TrEMBL

Q3U5L3, Q91VZ1

Conserved Domains (2) summary

cd07282
Location:90 → 213

PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2

cl12013
Location:231 → 464

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature