Pbp2 phosphatidylethanolamine binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pbp2provided by RGD
Official Full Name: phosphatidylethanolamine binding protein 2provided by RGD
Primary source: RGD:621707
See related: EnsemblRapid:ENSRNOG00000008667 AllianceGenome:RGD:621707
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pebp2; Pebp-2
Summary: Predicted to enable kinase inhibitor activity. Predicted to be involved in negative regulation of MAPK cascade. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 4q43

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (169887160..169888454, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (168155827..168157121, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (169091841..169093135, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data show that phosphatidylethanolamine binding protein 2 (pebp-2) is a testis-specific 21-kDa protein found within late meiotic and haploid germ cells and colocalizes with members of the MAP kinase pathway in late spermatocytes and spermatids
Title: Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylethanolamine-binding protein 2

Names: phosphatidylethanlomine binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105756.1 → NP_001099226.1 phosphatidylethanolamine-binding protein 2

See identical proteins and their annotated locations for NP_001099226.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6IMG4, M0RB80

Related

ENSRNOP00000066809.1, ENSRNOT00000011461.7

Conserved Domains (1) summary

cd00866
Location:23 → 171

PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes