Nlrp1b NLR family, pyrin domain containing 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrp1bprovided by MGI
Official Full Name: NLR family, pyrin domain containing 1Bprovided by MGI
Primary source: MGI:MGI:3582959
See related: Ensembl:ENSMUSG00000070390 AllianceGenome:MGI:3582959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nalp1b
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and nucleic acid binding activity. Acts upstream of or within protein catabolic process and pyroptotic inflammatory response. Predicted to be located in nucleoplasm. Predicted to be part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human NLRP1 (NLR family pyrin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 11 B4; 11 43.23 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (71043400..71133340, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (71152574..71242514, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1beta Antibody.
Title: UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1β Antibody.
NLRP1B and NLRP3 Control the Host Response following Colonization with the Commensal Protist Tritrichomonas musculis.
Title: NLRP1B and NLRP3 Control the Host Response following Colonization with the Commensal Protist Tritrichomonas musculis.
NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice.
Title: NLRP1 inflammasome involves in learning and memory impairments and neuronal damages during aging process in mice.
Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production.
Title: Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production.
NLRP1B also encompassessome additional unique structural features.For instance, the NLRP1B bears a C-termi-nal caspase activation and recruitmentdomain (CARD).
Title: When Degradation Elicits the Alarm: N-Terminal Degradation of NLRP1B Unleashes Its Inflammasome Activity.
Lethal factor directly cleaves NLRP1B, inducing the N-end rule-mediated degradation of the NLRP1B N terminus and freeing the NLRP1B C terminus to activate caspase-1.
Title: N-terminal degradation activates the NLRP1B inflammasome.
NLRP1B senses cellular infection by distinct invasive pathogens.
Title: Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.
ASC-driven caspase-1 autoprocessing and speck formation are dispensable for the activation of caspase-1 and the NLRP1b inflammasome.
Title: Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation.
Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.
Title: Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.
Data suggest that caspase-1 autoproteolysis in NLR family pyrin domain containing 1b (NLRP1b) and NLR family pyrin domain containing 3 (NLRP3) inflammasome function may have implications for pathogen recognition and response.
Title: Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

D11Die21 (e-PCR), detects polymorphism
- UniSTS:226099

D11Die22 (e-PCR), detects polymorphism
- UniSTS:226100

D11Die36 (e-PCR), detects polymorphism
- UniSTS:226111

D11Die40 (e-PCR), detects polymorphism
- UniSTS:226116

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NLRP1 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLRP1 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of NLRP3 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 1b allele 2

Names: NACHT, LRR and PYD domains-containing protein 1b; NACHT-, LRR-, and PYD-containing protein 1 paralog b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040696.2 → NP_001035786.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform 1

See identical proteins and their annotated locations for NP_001035786.1

Status: VALIDATED

Source sequence(s)

AL662908, AL663042

Consensus CDS

CCDS36210.1

UniProtKB/Swiss-Prot

A1Z198

Related

ENSMUSP00000104156.3, ENSMUST00000108516.9

Conserved Domains (8) summary

cd08330
Location:1084 → 1164

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:630 → 658

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:573 → 598

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:132 → 297

NACHT; NACHT domain

pfam13553
Location:812 → 1064

FIIND; Function to find

pfam17776
Location:426 → 535

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:370 → 424

NOD2_WH; NOD2 winged helix domain

cl39015
Location:592 → 721

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001162414.2 → NP_001155886.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform 3

See identical proteins and their annotated locations for NP_001155886.1

Status: VALIDATED

Source sequence(s)

AL662908, AL663042

Consensus CDS

CCDS48839.1

UniProtKB/Swiss-Prot

A1Z198, F6R9S5, Q2LK61, Q2LKV8

UniProtKB/TrEMBL

A0A1G5SJ87

Related

ENSMUSP00000104155.3, ENSMUST00000108515.9

Conserved Domains (7) summary

cd08330
Location:1087 → 1167

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:633 → 661

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:132 → 300

NACHT; NACHT domain

pfam13553
Location:815 → 1067

FIIND; Function to find

pfam17776
Location:426 → 538

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:370 → 424

NOD2_WH; NOD2 winged helix domain

cl39015
Location:627 → 724

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

NR_176629.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL662908, AL663042

Related

ENSMUST00000136493.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

71043400..71133340 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314698.2 → XP_017170187.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform X1

UniProtKB/Swiss-Prot

A1Z198

Conserved Domains (8) summary

cd08330
Location:1084 → 1164

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:630 → 658

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:573 → 598

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:132 → 297

NACHT; NACHT domain

pfam13553
Location:812 → 1064

FIIND; Function to find

pfam17776
Location:426 → 535

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:370 → 424

NOD2_WH; NOD2 winged helix domain

cl39015
Location:592 → 721

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006533907.3 → XP_006533970.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform X2

See identical proteins and their annotated locations for XP_006533970.1

UniProtKB/TrEMBL

A0A1G5SJ87

Conserved Domains (7) summary

cd08330
Location:1030 → 1110

CARD_ASC_NALP1; Caspase activation and recruitment domain found in Human ASC, NALP1, and similar proteins

sd00033
Location:576 → 604

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:75 → 243

NACHT; NACHT domain

pfam13553
Location:758 → 1010

FIIND; Function to find

pfam17776
Location:369 → 481

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:313 → 367

NOD2_WH; NOD2 winged helix domain

cl39015
Location:570 → 667

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_017314699.2 → XP_017170188.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform X3

Conserved Domains (3) summary

pfam05729
Location:132 → 297

NACHT; NACHT domain

pfam17776
Location:426 → 535

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:370 → 424

NOD2_WH; NOD2 winged helix domain
XM_017314700.1 → XP_017170189.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform X4

Conserved Domains (3) summary

pfam05729
Location:132 → 297

NACHT; NACHT domain

pfam17776
Location:426 → 535

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:370 → 424

NOD2_WH; NOD2 winged helix domain
XM_017314701.1 → XP_017170190.1 NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform X5

Conserved Domains (3) summary

pfam05729
Location:132 → 297

NACHT; NACHT domain

pfam17776
Location:426 → 535

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:370 → 424

NOD2_WH; NOD2 winged helix domain

RNA

XR_001780037.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001039680.1: Suppressed sequence

Description

NM_001039680.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A1Z198.1	GenPept	UniProtKB/Swiss-Prot:A1Z198
Q0GKD5.1	GenPept	UniProtKB/Swiss-Prot:Q0GKD5
Q2LKV2.1	GenPept	UniProtKB/Swiss-Prot:Q2LKV2
Q2LKV5.1	GenPept	UniProtKB/Swiss-Prot:Q2LKV5
Q2LKW6.1	GenPept	UniProtKB/Swiss-Prot:Q2LKW6