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    Zc3h18 zinc finger CCCH-type containing 18 [ Mus musculus (house mouse) ]

    Gene ID: 76014, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zc3h18provided by MGI
    Official Full Name
    zinc finger CCCH-type containing 18provided by MGI
    Primary source
    MGI:MGI:1923264
    See related
    Ensembl:ENSMUSG00000017478 AllianceGenome:MGI:1923264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nhn1; 1190001B23Rik; 5830416A07Rik
    Summary
    Predicted to enable mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Predicted to be involved in RNA destabilization. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Is expressed in respiratory system cartilage; sensory organ; skeleton; and vibrissa. Orthologous to human ZC3H18 (zinc finger CCCH-type containing 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.4), limb E14.5 (RPKM 12.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h18 in Genome Data Viewer
    Location:
    8 E1; 8 70.98 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123103298..123144104)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122376564..122417365)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46056 Neighboring gene STARR-positive B cell enhancer ABC_E6697 Neighboring gene thyrotropin releasing hormone receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E6698 Neighboring gene interleukin 17C Neighboring gene STARR-positive B cell enhancer ABC_E9324 Neighboring gene STARR-positive B cell enhancer ABC_E8269 Neighboring gene cytochrome b-245, alpha polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    2. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    3. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
    4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 18
    Names
    conserved nuclear protein Nhn1
    nuclear protein NHN1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029993.1 → NP_001025164.1  zinc finger CCCH domain-containing protein 18 isoform a

      See identical proteins and their annotated locations for NP_001025164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK004428, AK017933, AK031413, BC030495, BY235998
      Consensus CDS
      CCDS22735.1
      UniProtKB/TrEMBL
      G3X8T2
      Related
      ENSMUSP00000017622.6, ENSMUST00000017622.12

    2. NM_001029994.1 → NP_001025165.1  zinc finger CCCH domain-containing protein 18 isoform b

      See identical proteins and their annotated locations for NP_001025165.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      BC030495, BY235998, CD348551
      Consensus CDS
      CCDS22736.1
      UniProtKB/Swiss-Prot
      Q0P678, Q3TKW3, Q52KI3, Q6KAL8, Q9CU64
      Related
      ENSMUSP00000090761.6, ENSMUST00000093073.12
      Conserved Domains (1) summary
      smart00356
      Location:211 → 239
      ZnF_C3H1; zinc finger

    3. NM_001310650.1 → NP_001297579.1  zinc finger CCCH domain-containing protein 18 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AK159881, BC094330, BM900035, BY125794, BY235998
      Consensus CDS
      CCDS80941.1
      UniProtKB/TrEMBL
      H3BIW0
      Related
      ENSMUSP00000134743.2, ENSMUST00000176629.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123103298..123144104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243834.2 → XP_030099694.1  zinc finger CCCH domain-containing protein 18 isoform X5

      Conserved Domains (1) summary
      pfam18044
      Location:218 → 239
      zf-CCCH_4; CCCH-type zinc finger

    2. XM_006531470.4 → XP_006531533.1  zinc finger CCCH domain-containing protein 18 isoform X3

      Conserved Domains (2) summary
      pfam18044
      Location:254 → 275
      zf-CCCH_4; CCCH-type zinc finger
      NF000535
      Location:21 → 165
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

    3. XM_006531469.4 → XP_006531532.1  zinc finger CCCH domain-containing protein 18 isoform X1

      Conserved Domains (2) summary
      NF000535
      Location:21 → 165
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cl39030
      Location:254 → 299
      zf_CCCH_4; Zinc finger domain

    4. XM_011248538.2 → XP_011246840.1  zinc finger CCCH domain-containing protein 18 isoform X2

      Conserved Domains (2) summary
      NF000535
      Location:21 → 165
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      cl39030
      Location:254 → 299
      zf_CCCH_4; Zinc finger domain

    5. XM_036154364.1 → XP_036010257.1  zinc finger CCCH domain-containing protein 18 isoform X4

      Conserved Domains (2) summary
      NF000535
      Location:21 → 165
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
      pfam18044
      Location:254 → 275
      zf-CCCH_4; CCCH-type zinc finger

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024268.1: Suppressed sequence

      Description
      NM_024268.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0P678.1 GenPept UniProtKB/Swiss-Prot:Q0P678

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