Gng13 guanine nucleotide binding protein (G protein), gamma 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gng13provided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), gamma 13provided by MGI
Primary source: MGI:MGI:1925616
See related: Ensembl:ENSMUSG00000025739 AllianceGenome:MGI:1925616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hg3j; Ggamma13; 1500031D04Rik
Summary: Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and sensory perception of taste. Located in dendrite. Part of heterotrimeric G-protein complex. Is active in synapse. Is expressed in brain; gonad; gut; and liver. Orthologous to human GNG13 (G protein subunit gamma 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 73.0), cortex adult (RPKM 33.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.82 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25936146..25938076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25717172..25719102)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G protein gamma subunit, Ggamma13, is expressed in a spatiotemporal manner similar to those of Galphaolf and Galphai2 in the olfactory system and vomeronasal organ, respectively. In addition, Ggamma13 was found in the glomeruli of the main olfactory bulb but was largely absent in the glomeruli of the accessory olfactory bulb; and to play an essential role in odor-triggered social behaviors including male-male aggression.
Title: G protein γ subunit Gγ13 is essential for olfactory function and aggressive behavior in mice.
Differential function of Ggamma13 in rod bipolar and ON cone bipolar cells
Title: Differential function of Gγ13 in rod bipolar and ON cone bipolar cells.
The results of this study indicated that Galphaolf exclusively forms a functional heterotrimeric G-protein with Gbeta1 and Ggamma13 in OSNs, mediating olfactory signal transduction
Title: Heterotrimeric G protein subunit Gγ13 is critical to olfaction.
Data suggest that proteins of the taste transduction cascade (alpha-gustducin, G-protein gamma13, and phospholipase Cbeta2) are expressed in testis and are involved in spermatogenesis.
Title: Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice.
Ggamma13, a divergent member of the Ggamma subunit family, is abundantly expressed in the cilia of olfactory sensory neurons and and interacts with Ric-8B.
Title: Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons.
Gng13 mRNA is highly restricted to the cortex of the XX gonad during sexual differentiation, suggesting a role for this gene during ovarian development.
Title: Sexual dimorphism of G-protein subunit Gng13 expression in the cortical region of the developing mouse ovary.
Ggamma13 interacts with PDZ domain-containing proteins
Title: Ggamma13 interacts with PDZ domain-containing proteins.
Ggamma13 subunit is coexpressed in physiologically ON-type cone bipolar cells with Gbeta3 and Gbeta4 but is not present in OFF-type bipolar cells.
Title: G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gng13 (e-PCR), detects polymorphism
- UniSTS:502770

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta-subunit binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Names: heterotrimeric guanine nucleotide-binding protein 3j

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357782.1 → NP_001344711.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Status: VALIDATED

Source sequence(s)

AC134908, EH103048

Consensus CDS

CCDS37503.1

UniProtKB/Swiss-Prot

Q9JMF3

Related

ENSMUSP00000110760.4, ENSMUST00000115108.4

Conserved Domains (1) summary

cd00068
Location:6 → 61

GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
NM_022422.5 → NP_071867.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

See identical proteins and their annotated locations for NP_071867.1

Status: VALIDATED

Source sequence(s)

BU554843, EH103048

Consensus CDS

CCDS37503.1

UniProtKB/Swiss-Prot

Q9JMF3

Related

ENSMUSP00000131648.2, ENSMUST00000172002.8

Conserved Domains (1) summary

cd00068
Location:6 → 61

GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors