Gab2 growth factor receptor bound protein 2-associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gab2provided by MGI
Official Full Name: growth factor receptor bound protein 2-associated protein 2provided by MGI
Primary source: MGI:MGI:1333854
See related: Ensembl:ENSMUSG00000004508 AllianceGenome:MGI:1333854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p97; D130058I17Rik
Summary: Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including phosphatidylinositol 3-kinase/protein kinase B signal transduction; positive regulation of epithelial cell migration; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Located in membrane raft. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to human GAB2 (GRB2 associated binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 14.2), testis adult (RPKM 7.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.39 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (96730958..96958158)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (97081751..97308951)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor-associated macrophages.
Title: Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.
Title: The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.
Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.
Title: Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.
Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells.
Title: Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells.
Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.
Title: Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.
Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain.
Title: Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain.
Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice.
Title: Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice.
Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction.
Title: Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction.
G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway.
Title: G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway.
Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.
Title: Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.

Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI463667 (e-PCR)
- UniSTS:159671

D7Mit367 (e-PCR), detects polymorphism
- UniSTS:131265

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GRB2-associated-binding protein 2

Names: GRB2-associated binder 2; Grb2 associated binder 2; PH domain-containing adaptor molecule p97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162477.1 → NP_001155949.1 GRB2-associated-binding protein 2 isoform 2

See identical proteins and their annotated locations for NP_001155949.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AC074047, AC155933

Consensus CDS

CCDS85340.1

UniProtKB/Swiss-Prot

Q9R1X3, Q9Z1S8

UniProtKB/TrEMBL

Q3ZB59

Related

ENSMUSP00000146200.2, ENSMUST00000206791.2

Conserved Domains (3) summary

pfam00169
Location:9 → 118

PH; PH domain

cl17171
Location:6 → 128

PH-like; Pleckstrin homology-like domain

cl23751
Location:542 → 628

Plasmodium_Vir; Plasmodium vivax Vir protein
NM_010248.2 → NP_034378.2 GRB2-associated-binding protein 2 isoform 1

See identical proteins and their annotated locations for NP_034378.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC074047, AC155933

Consensus CDS

CCDS21455.1

UniProtKB/TrEMBL

Q3ZB56, Q3ZB57

Related

ENSMUSP00000004622.6, ENSMUST00000004622.7

Conserved Domains (3) summary

pfam00169
Location:9 → 118

PH; PH domain

cl17171
Location:6 → 128

PH-like; Pleckstrin homology-like domain

cl23751
Location:546 → 629

Plasmodium_Vir; Plasmodium vivax Vir protein