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    Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [ Mus musculus (house mouse) ]

    Gene ID: 66094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lsm7provided by MGI
    Official Full Name
    LSM7 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by MGI
    Primary source
    MGI:MGI:1913344
    See related
    Ensembl:ENSMUSG00000035215 AllianceGenome:MGI:1913344
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0910001B06Rik; 1110033F18Rik
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of several cellular components, including Lsm1-7-Pat1 complex; spliceosomal complex; and spliceosomal snRNP complex. Is expressed in central nervous system and sensory organ. Orthologous to human LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 88.2), liver E14 (RPKM 73.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsm7 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80688659..80691043, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80852825..80855209, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 1982 Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E11447 Neighboring gene STARR-positive B cell enhancer ABC_E6885 Neighboring gene signal peptide peptidase like 2B Neighboring gene transmembrane protease, serine 9 Neighboring gene translocase of inner mitochondrial membrane 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role for LSM genes in the regulation of circadian rhythms. Perez-Santángelo S, et al. Proc Natl Acad Sci U S A, 2014 Oct 21. PMID 25288739, Free PMC Article
    2. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Kim J, et al. Mol Cell Biol, 2020 Oct 13. PMID 32839293, Free PMC Article
    3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Lsm2-8 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Lsm2-8 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U6 snRNA-associated Sm-like protein LSm7
    Names
    LSM7 homolog, U6 small nuclear RNA associated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359148.1 → NP_001346077.1  U6 snRNA-associated Sm-like protein LSm7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166937, AK013355, BC027511
      Conserved Domains (1) summary
      cd01729
      Location:10 → 98
      LSm7; Like-Sm protein 7

    2. NM_001359149.1 → NP_001346078.1  U6 snRNA-associated Sm-like protein LSm7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC166937, AK013355, BC027511
      Conserved Domains (1) summary
      cd01729
      Location:20 → 108
      LSm7; Like-Sm protein 7

    3. NM_001359150.1 → NP_001346079.1  U6 snRNA-associated Sm-like protein LSm7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166937, AK013355, BC027511
      Related
      ENSMUST00000220406.2
      Conserved Domains (1) summary
      cd01729
      Location:21 → 107
      LSm7; Like-Sm protein 7

    4. NM_025349.2 → NP_079625.1  U6 snRNA-associated Sm-like protein LSm7 isoform 4

      See identical proteins and their annotated locations for NP_079625.1

      Status: VALIDATED

      Source sequence(s)
      AK013355, BC027511
      Consensus CDS
      CCDS35987.1
      UniProtKB/Swiss-Prot
      Q9CQQ8
      Related
      ENSMUSP00000044993.9, ENSMUST00000035775.9
      Conserved Domains (1) summary
      cd01729
      Location:9 → 97
      LSm7; Like-Sm protein 7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      80688659..80691043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQQ8.1 GenPept UniProtKB/Swiss-Prot:Q9CQQ8

    Gene LinkOut

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