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    Ceacam1 CEA cell adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81613, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ceacam1provided by RGD
    Official Full Name
    CEA cell adhesion molecule 1provided by RGD
    Primary source
    RGD:67396
    See related
    EnsemblRapid:ENSRNOG00000020578 AllianceGenome:RGD:67396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bgp; BGPR; CD66a; Ccam1
    Summary
    Enables several functions, including bile acid transmembrane transporter activity; calmodulin binding activity; and protein homodimerization activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; insulin catabolic process; and regulation of signal transduction. Acts upstream of or within positive regulation of MAP kinase activity. Located in several cellular components, including adherens junction; basal plasma membrane; and lateral plasma membrane. Orthologous to several human genes including CEACAM1 (CEA cell adhesion molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 224.1), Lung (RPKM 110.0) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ceacam1 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (90171401..90187810, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (81043595..81060050, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82327955..82344345, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096895 Neighboring gene lipase E, hormone sensitive type Neighboring gene C-X-C motif chemokine ligand 17 Neighboring gene uncharacterized LOC102549342 Neighboring gene glutamate-rich 4 Neighboring gene distal membrane arm assembly component 2 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Toll-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables bile acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables granulocyte colony-stimulating factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell adhesion via plasma-membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in common myeloid progenitor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in common myeloid progenitor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in granulocyte colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in granulocyte colony-stimulating factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytotoxic T cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytotoxic T cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of granulocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of homophilic cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasculogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of blood vessel remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endothelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epidermal growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of homophilic cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing, spreading of cells ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of T cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of T cell receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cell adhesion molecule CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1
    Names
    ATP-dependent taurocolate-carrier protein
    C-CAM 105
    CEA-related cell adhesion molecule 1 (bone gamma-carboxyglutamic acid (Gla) protein) (osteocalcin)
    GP110
    bone gamma-carboxyglutamic acid (Gla) protein
    carcinoembryonic antigen related cell adhesion molecule 1
    carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    cell-CAM 105
    ecto-ATPase
    osteocalcin
    pp120
    pp120/ecto-ATPase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033860.1NP_001029032.1  cell adhesion molecule CEACAM1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001029032.1

      Status: VALIDATED

      Source sequence(s)
      BC061740, J04963, JAXUCZ010000001, M92848
      UniProtKB/Swiss-Prot
      P16573, Q63093
      UniProtKB/TrEMBL
      A0A8I6A3J5, A6J963
      Related
      ENSRNOP00000046654.3, ENSRNOT00000051892.8
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:331410
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146233
      Ig; Immunoglobulin domain
    2. NM_001033861.1NP_001029033.1  cell adhesion molecule CEACAM1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001029033.1

      Status: VALIDATED

      Source sequence(s)
      AJ277105, BC061740, J04963, JAXUCZ010000001, M92848
      UniProtKB/TrEMBL
      A0A8I6A3J5, F7EVH5, Q9JHL6
      Related
      ENSRNOP00000027933.4, ENSRNOT00000027933.8
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:331410
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146233
      Ig; Immunoglobulin domain
    3. NM_001033862.1NP_001029034.1  cell adhesion molecule CEACAM1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001029034.1

      Status: VALIDATED

      Source sequence(s)
      BC061740, J04963, JAXUCZ010000001, M92848, X91137
      UniProtKB/TrEMBL
      A6J966
      Related
      ENSRNOP00000074820.1, ENSRNOT00000090629.3
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:331410
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146233
      Ig; Immunoglobulin domain
    4. NM_031755.2NP_113943.1  cell adhesion molecule CEACAM1 isoform 4 precursor

      See identical proteins and their annotated locations for NP_113943.1

      Status: VALIDATED

      Source sequence(s)
      AJ277104, BC061740, J04963, JAXUCZ010000001, M92848
      UniProtKB/TrEMBL
      F7EUP5, F7F6B2, Q9JHL7
      Related
      ENSRNOP00000031260.4, ENSRNOT00000029487.9
      Conserved Domains (4) summary
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:331410
      IG_like; Immunoglobulin like
      pfam13895
      Location:240318
      Ig_2; Immunoglobulin domain
      cl11960
      Location:146233
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      90171401..90187810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091997.2XP_038947925.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X2

      Conserved Domains (2) summary
      cd05740
      Location:795
      IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
      cd20948
      Location:104179
      IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains
    2. XM_063275061.1XP_063131131.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

      UniProtKB/TrEMBL
      A6J966
      Related
      ENSRNOP00000085270.1, ENSRNOT00000103781.2
    3. XM_039092002.2XP_038947930.1  carcinoembryonic antigen-related cell adhesion molecule 1 isoform X3

      UniProtKB/TrEMBL
      Q78E86
      Conserved Domains (1) summary
      cd05774
      Location:36140
      IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)